ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1990
Adsorption of 5'-adenosine monophosphate onto precipitated calcium phosphate: effects of inorganic polyphosphates and carbamyl phosphate.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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8 citing papers in PubMed, 14 citations in OpenAlex.
- Molecularly Imprinted Polymeric Nanoparticles as Drug Delivery System for Tenofovir, an Acyclic Nucleoside Phosphonate Antiviral.Pharmaceutics · 2024Article
- Divalent cations modify adsorption of 5'-AMP onto precipitated calcium phosphate: a model for cation modulation of adsorptive processes in primitive aqueous environments.Journal of molecular evolution · 1996Article
- Adsorption of 5'-AMP and catalytic synthesis of 5'-ADP onto phosphate surfaces: correlation to solid matrix structures.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- Reactions involving carbamyl phosphate in the presence of precipitated calcium phosphate with formation of pyrophosphate: a model for primitive energy-conservation pathways.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- Chirality and life.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- The binding and reactions of nucleotides and polynucleotides on iron oxide hydroxide polymorphs.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1993Article
- Pyrophosphate synthesis from phospho(enol)pyruvate catalyzed by precipitated magnesium phosphate with "enzyme-like" activity.Journal of molecular evolution · 1992Article
- The origin and amplification of biomolecular chirality.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1991Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this paper it is shown that the adsorption of 5'-adenosine monophosphate (5'-AMP) onto precipitated calcium phosphate exhibits a sigmoidal profile as revealed by isotherms at 45 degrees C. This result indicates a cooperative behavior in the adsorption of 5'-AMP. The relationship between adsorption capacity and surface area of the sedimented matrix may be interpreted as an indication that there is a monolayer of the absorbed nucleotide on the solid surface. The pH dependence of adsorption suggests that the negatively charged phosphoryl group of 5'-AMP interacts with a positively charged site (possibly Ca2+) on the matrix surface. The adsorption of the nucleotide is markedly decreased at pH values above 8.0. The Dixon-like plot of the effect of pH suggests an inhibitory role of hydroxyl ions in the adsorption of 5'-AMP. At pH 7.5, other anions such as pyrophosphate, tripolyphosphate and carbamyl phosphate also inhibit the adsorption of the nucleotide, probably by interacting with its adsorption site. We suggest that these phosphorylated molecules could have played a role in chemical evolution by modulating the amount of nucleotides adsorbed onto mineral surfaces. The significance of these phenomena in chemical evolution is discussed.
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