ArticleNorth American journal of medical sciences2013
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study.
Article in North American journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Merkel cell polyomavirus and Langerhans cell neoplasm.Cell communication and signaling : CCS · 2018Pooled it
- Chemokine Expression in Well-Differentiated Liposarcoma May Be Involved in the Tumorigenesis of Lymphoplasmacytic Lymphoma: A Case Study.Cancer reports (Hoboken, N.J.) · 2025Article
- Case report: Common clonal origin of concurrent langerhans cell histiocytosis and acute myeloid leukemia.Frontiers in oncology · 2022Article
- Chronic lymphocytic leukemia/small lymphocytic lymphoma complicated with skin Langerhans cell sarcoma: A case report.World journal of clinical cases · 2021Article
- Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomic Alterations Distinct from Follicular Dendritic Cell Sarcoma.The oncologist · 2021Article
- Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.The journal of pathology. Clinical research · 2021Article
- Epstein-Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report.Frontiers in oncology · 2021Article
- Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report.Virchows Archiv : an international journal of pathology · 2019Article
- Update on the classification of T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms.Expert review of hematology · 2019Review
- Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy.Journal of clinical and experimental hematopathology : JCEH · 2018Article
- KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma.Diagnostic pathology · 2018Article
- Langerhans cell sarcoma of the skin in association with superficial atypical Langerhans cell proliferation.Rare tumors · 2017Article
- Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.Virchows Archiv : an international journal of pathology · 2017Article
- Article
- Cytological findings of langerhans cell sarcoma in a case of quintuple cancer.Diagnostic cytopathology · 2017Article
- Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms.Expert review of hematology · 2017Review
- Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review.Oncology letters · 2016Article
- Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.Blood · 2016Review
- Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.Nature communications · 2016Article
- The 2016 revision of the World Health Organization classification of lymphoid neoplasms.Blood · 2016Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundthe phenomenon that histiocytic/dendritic cell sarcomas may be transformed from lymphoproliferative diseases is dubbed 'transdifferentiation'. Langerhans cell sarcoma (LCS) transdifferentiated from chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) is extremely rare. The underlying mechanisms of LCS tumorogenesis and its transdifferentiation from CLL/SLL are largely unknown.
aimsthe authors strive to further characterize LCS, to understand the potential molecular changes in LCS and the underlying mechanisms of CLL/SLL transformation to LCS. MATERIALS AND
methodsa progressively enlarging right inguinal lymph node from a 68-year-old female patient with a history of CLL was biopsied and submitted for flow cytometry analysis, routine hematoxylin, and eosin (H and E) stain and immunohistochemical study. Furthermore, clonality study (fluorescent in situ hybridization (FISH) analysis with a CLL panel probes) and BRAF V600E mutation study (pyrosequencing and immunostain) were performed.
resultstwo different neoplasms, LCS and CLL/SLL, were discovered to occur simultaneously in the same lymph node. These two entities were shown to be clonally related. More importantly, for the first time, BRAF V600E mutation was detected in LCS.
conclusionsLCS can be transdifferentiated from CLL/SLL and BRAF V600E mutation may provide the foundation for alternative therapy of LCS.
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