ArticleInternational journal of clinical and experimental pathology2013
Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Implant replacement and anaplastic large cell lymphoma associated with breast implants: a quantitative analysis.Frontiers in oncology · 2023Pooled it
- Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris.Tribology letters · 2025Article
- Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report about a Male Patient with Pectoral Implants.Breast care (Basel, Switzerland) · 2024Article
- 2022 Practice Recommendation Updates From the World Consensus Conference on BIA-ALCL.Aesthetic surgery journal · 2022Review
- Comprehensive Evaluation of the Current Knowledge on Breast Implant Associated-Anaplastic Large Cell Lymphoma.Archives of plastic surgery · 2022Article
- Article
- Comparison of outcomes between immediate implantbased and autologous reconstruction: 15-year, single-center experience in a propensity score-matched Chinese cohort.Cancer biology & medicine · 2021Article
- Breast implant-associated anaplastic large cell lymphoma with contralateral invasive lobular carcinoma.Radiology case reports · 2020Article
- Article
- Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Current Understanding and Recommendations for Management.Plastic surgery (Oakville, Ont.) · 2020Review
- Rare presentation of Waldenström macroglobulinemia post shoulder replacement and dynamic hip screw procedures.JSES open access · 2019Article
- Breast implant-associated anaplastic large cell lymphoma: a review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- Breast implant-associated anaplastic large cell lymphoma: Clinical and imaging findings at a large US cancer center.The breast journal · 2019Article
- Breast Implant-Associated Lymphoma.Deutsches Arzteblatt international · 2018Review
- Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.The American journal of surgical pathology · 2018Article
- Breast Implant-Associated Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature.Case reports in hematology · 2018Article
- Understanding rare adverse sequelae of breast implants: anaplastic large-cell lymphoma, late seromas, and double capsules.Gland surgery · 2017Review
- Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report and Review of the Literature.Case reports in oncological medicine · 2017Article
- Intravascular large B-cell lymphoma associated with silicone breast implant, HLA-DRB1*11:01, and HLA-DQB1*03:01 manifesting as macrophage activation syndrome and with severe neurological symptoms: a case report.Journal of medical case reports · 2016Article
- Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes.Annals of oncology : official journal of the European Society for Medical Oncology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a recently recognized clinical entity, with only 39 well-documented cases reported worldwide, including 3 fatalities. Because of its rarity, the clinical and pathologic features of this malignancy have yet to be fully defined. Moreover, the pathogenesis of ALCL in association with textured silicone gel breast implants is poorly understood. Here we report a case of BIA-ALCL arising in a 67-year-old woman with a mastectomy due to breast cancer followed by implantation of textured silicone gel breast prosthesis. The patient presented with breast enlargement and tenderness 8 years following reconstructive surgery. MRI revealed a fluid collection surrounding the affected breast implant. Pathologic examination confirmed the presence of malignant ALCL T cells that were CD30+, CD8+, CD15+, HLA-DR+, CD25+ ALK- and p53. A diagnosis of indolent BIA-ALCL was made since tumor cells were not found outside of the capsule. Interestingly, an extensive mixed lymphocytic infiltrate and ectopic lymphoid tissue (lymphoid neogenesis) adjacent to the fibrous implant capsule were present. The patient was treated with capsulectomy and implantation of new breast prostheses. Six months later, the patient was found to have BIA-ALCL involvement of an axillary lymph node with cytogenetic evolution of the tumor. To our knowledge, this is the sixth reported case of aggressive BIA-ALCL. Unique features of this case include the association with lymphoid neogenesis and the in vivo cytogenetic progression of the tumor. This case provides insight into the potential role of chronic inflammation and genetic instability in the pathogenesis of BIA-ALCL.
Indexed as
Identifiers
23923082PMC3726980W1492971972What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.