ArticlePloS one2013
Amiodarone inhibits apamin-sensitive potassium currents.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Thyrotropin Directly Affects Cardiac Electrophysiology and Is Associated With AF Prevalence.Circulation. Arrhythmia and electrophysiology · 2025Article
- Review
- The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.Pflugers Archiv : European journal of physiology · 2021Review
- Inhibition of Small-Conductance, CaFrontiers in pharmacology · 2021Article
- Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Causal Link between Ventricular Ectopy and Concussion.Case reports in medicine · 2020Article
- Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts.Heart rhythm · 2019Article
- Concomitant SK current activation and sodium current inhibition cause J wave syndrome.JCI insight · 2018Article
- Sex-specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles.The Journal of physiology · 2018Article
- Ondansetron blocks wild-type and p.F503L variant small-conductance CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Correction to: Inhibition of the KPflugers Archiv : European journal of physiology · 2018Article
- Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits.Heart rhythm · 2018Article
- Inhibition of the KPflugers Archiv : European journal of physiology · 2018Article
- The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome.Korean circulation journal · 2016Article
- Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.Journal of cardiovascular pharmacology · 2015Review
- Small-Conductance Calcium-Activated Potassium Current Is Activated During Hypokalemia and Masks Short-Term Cardiac Memory Induced by Ventricular Pacing.Circulation · 2015Article
- Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias.Heart rhythm · 2015Review
- SK channels and ventricular arrhythmias in heart failure.Trends in cardiovascular medicine · 2015Review
- Small conductance calcium-activated potassium current is important in transmural repolarization of failing human ventricles.Circulation. Arrhythmia and electrophysiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundApamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular fibrillation (VF) in failing ventricles.
objectiveTo test the hypothesis that amiodarone inhibits I KAS in human embryonic kidney 293 (HEK-293) cells.
methodsWe used the patch-clamp technique to study I KAS in HEK-293 cells transiently expressing human SK2 before and after amiodarone administration.
resultsAmiodarone inhibited IKAS in a dose-dependent manner (IC50, 2.67 ± 0.25 µM with 1 µM intrapipette Ca(2+)). Maximal inhibition was observed with 50 µM amiodarone which inhibited 85.6 ± 3.1% of IKAS induced with 1 µM intrapipette Ca(2+) (n = 3). IKAS inhibition by amiodarone was not voltage-dependent, but was Ca(2+)-dependent: 30 µM amiodarone inhibited 81.5±1.9% of I KAS induced with 1 µM Ca(2+) (n = 4), and 16.4±4.9% with 250 nM Ca(2+) (n = 5). Desethylamiodarone, a major metabolite of amiodarone, also exerts voltage-independent but Ca(2+) dependent inhibition of I KAS.
conclusionBoth amiodarone and desethylamiodarone inhibit I KAS at therapeutic concentrations. The inhibition is independent of time and voltage, but is dependent on the intracellular Ca(2+) concentration. SK2 current inhibition may in part underlie amiodarone's effects in preventing electrical storm in failing ventricles.
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Registered trials
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