SynthesisPloS one2013
The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.Health technology assessment (Winchester, England) · 2024Pooled it
- Pooled it
- The frequency of maternal morbidity: A systematic review of systematic reviews.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2018Pooled it
- Postpartum Venous Thromboembolism: Altitudinal Gradients, Decadal Trends, and PE-Specific Risk Profiling in Highland Populations.Canadian respiratory journal · 2026Article
- Rates of venous thromboembolism associated with acute psychiatric admission: A retrospective cohort study.Experimental and therapeutic medicine · 2024Article
- Approach to the Patient: Hormonal Therapy in Transgender Adults With Complex Medical Histories.The Journal of clinical endocrinology and metabolism · 2024Article
- Prevention, diagnosis, and management of PE and DVT in pregnant women.Hematology. American Society of Hematology. Education Program · 2023Review
- Observational
- Pregnancy and thrombosis risk for women without a history of thrombotic events: a retrospective study of the real risks.Thrombosis journal · 2022Article
- Standardizing definitions for bleeding events in studies including pregnant women: A call to action.Research and practice in thrombosis and haemostasis · 2022Article
- Safety and effectiveness of fondaparinux as a postpartum thromboprophylaxis during puerperium among muslim women: A single centre prospective study.Frontiers in pharmacology · 2022Article
- Concomitant use of combined hormonal contraceptives and antifibrinolytic agents for the management of heavy menstrual bleeding: A practice pattern survey.Thrombosis research · 2021Article
- VTE risk assessment in pregnancy.Research and practice in thrombosis and haemostasis · 2020Article
- Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study.Blood research · 2019Article
- Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
- Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters.Drug safety · 2017Article
- Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England.Journal of the American Heart Association · 2017Article
- Case-crossover study to examine the change in postpartum risk of pulmonary embolism over time.BMC pregnancy and childbirth · 2017Article
- Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study.BMJ (Clinical research ed.) · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linked primary and secondary care data to determine an optimum definition for estimating the incidence of first VTE in and around pregnancy; and secondly to conduct a systematic literature review of studies on perinatal VTE incidence with the purpose of comparing our estimates.
methodsWe used primary care data from the Clinical Practice Research Datalink (CPRD), which incorporates linkages to secondary care contained within Hospital Episode Statistics (HES) between 1997 and 2010 to estimate the incidence rate of VTE in the antepartum and postpartum period. We systematically searched the literature on the incidence of VTE during antepartum and postpartum periods and performed a meta-analysis to provide comparison.
findingsUsing combined CPRD and HES data and a restrictive VTE definition, the absolute rate during the antepartum period and first six weeks postpartum (early postpartum) were 99 (95%CI 85-116) and 468 (95%CI 391-561) per 100,000 person-years respectively. These were comparable to the pooled estimates from our meta-analysis (using studies after 2005) during the antepartum period (118/100,000 person-years) and early postpartum (424/100,000 person-years). When we used only secondary care data to identify VTE events, incidence was lower during the early postpartum period (308/100,000 person-years), whereas relying only on primary care data lead to lower incidence during the time around delivery, but higher rates during the postpartum period (558/100,000 person-years).
conclusionUsing combined CPRD and HES data gives estimates of the risk of VTE in and around pregnancy that are comparable to the existing literature. It also provides more accurate estimation of the date of VTE diagnosis which will allow risk stratification during specific pregnancy and postpartum periods.
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