ArticlePloS one2013
The aqueous extract of Ficus religiosa induces cell cycle arrest in human cervical cancer cell lines SiHa (HPV-16 Positive) and apoptosis in HeLa (HPV-18 positive).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Comparative Evaluation of the Cytotoxic Effect of Dysphania ambrosioides Extracts Against Human Breast and Cervical Cancer Cells.Chemistry & biodiversity · 2026Article
- In-Vitro Cytotoxic, Antiproliferative and Apoptotic Activity of Siddha Formulation Nandhi Mezhugu (NM) Against Hela Cell Line.Applied biochemistry and biotechnology · 2024Article
- 1,5,6-Trimethoxy-2,7-dihydroxyphenanthrene fromInternational journal of molecular sciences · 2023Article
- A standardized protocol for genetically stable artificial seed production of Ficus religiosa L. using ISSR fingerprinting.Journal of applied genetics · 2023Article
- Dibenzylideneacetone Induces Apoptosis in Cervical Cancer Cells through Ros-Mediated Mitochondrial Damage.Antioxidants (Basel, Switzerland) · 2023Article
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- Medicinal plants and natural compounds against acyclovir-resistant HSV infections.Frontiers in microbiology · 2022Review
- Phytochemistry, Pharmacological Properties, and Recent Applications ofPlants (Basel, Switzerland) · 2021Review
- Health-promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig,Food science & nutrition · 2021Article
- The Effect of Indian Fig Fruit Extract on Human Papilloma Virus containing Cervical Cancer Cells (HeLa) by Decreasing the HPV18 L1 Gene Load.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Phytochemical profile and antiproliferative effect of Ficus crocata extracts on triple-negative breast cancer cells.BMC complementary medicine and therapies · 2020Article
- Involvement of p53-dependent apoptosis signal in antitumor effect of Colchicine on human papilloma virus (HPV)-positive human cervical cancer cells.Bioscience reports · 2020Article
- Exploring the Pharmacological Potentials of Biosurfactant Derived from Planococcus maritimus SAMP MCC 3013.Current microbiology · 2020Article
- Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo.Drug design, development and therapy · 2019Article
- Anticancer Potential of Fruit Extracts fromTheScientificWorldJournal · 2019Article
- Anti-proliferative effect of novel primary cetyl alcohol derived sophorolipids against human cervical cancer cells HeLa.PloS one · 2017Article
- 1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.International journal of molecular sciences · 2016Article
- Alpha-linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expression in human cervical cancer cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Natural products are being extensively explored for their potential to prevent as well as treat cancer due to their ability to target multiple molecular pathways. Ficus religiosa has been shown to exert diverse biological activities including apoptosis in breast cancer cell lines. In the present study, we report the anti-neoplastic potential of aqueous extract of F. religiosa (FRaq) bark in human cervical cancer cell lines, SiHa and HeLa. FRaq altered the growth kinetics of SiHa (HPV-16 positive) and HeLa (HPV-18 positive) cells in a dose-dependent manner. It blocked the cell cycle progression at G1/S phase in SiHa that was characterized by an increase in the expression of p53, p21 and pRb proteins with a simultaneous decrease in the expression of phospho Rb (ppRb) protein. On the other hand, in HeLa, FRaq induced apoptosis through an increase in intracellular Ca(2+) leading to loss of mitochondrial membrane potential, release of cytochrome-c and increase in the expression of caspase-3. Moreover, FRaq reduced the migration as well as invasion capability of both the cervical cancer cell lines accompanied with downregulation of MMP-2 and Her-2 expression. Interestingly, FRaq reduced the expression of viral oncoproteins E6 and E7 in both the cervical cancer cell lines. All these data suggest that F. religiosa could be explored for its chemopreventive potential in cervical cancer.
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