ArticlePloS one2013
A robotics-based behavioral paradigm to measure anxiety-related responses in zebrafish.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Fish adapt and dynamically avoid an approaching robotic fish across repeated exposures.Scientific reports · 2026Article
- Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways.Natural products and bioprospecting · 2023Article
- Lactobacillus rhamnosus GG treatment potentiates ethanol-induced behavioral changes through modulation of intestinal epithelium in Danio rerio.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Entropy and Fractal Techniques for Monitoring Fish Behaviour and Welfare in Aquacultural Precision Fish Farming-A Review.Entropy (Basel, Switzerland) · 2023Review
- Ecology of fear in highly invasive fish revealed by robots.iScience · 2022Article
- Going Beyond the "Synthetic Method": New Paradigms Cross-Fertilizing Robotics and Cognitive Neuroscience.Frontiers in psychology · 2022Review
- Acute Citalopram administration modulates anxiety in response to the context associated with a robotic stimulus in zebrafish.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Opposite valence social information provided by bio-robotic demonstrators shapes selection processes in the green bottle fly.Journal of the Royal Society, Interface · 2021Article
- Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.Biomolecules · 2021Review
- Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects.Frontiers in behavioral neuroscience · 2021Review
- Article
- Model-based feedback control of live zebrafish behavior via interaction with a robotic replica.IEEE transactions on robotics : a publication of the IEEE Robotics and Automation Society · 2020Article
- Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish.Behavioural brain research · 2020Article
- The Logic of Interactive Biorobotics.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- Zebrafish Adjust Their Behavior in Response to an Interactive Robotic Predator.Frontiers in robotics and AI · 2019Article
- Benefits and limitations of three-dimensional printing technology for ecological research.BMC ecology · 2018Article
- Closed-loop control of zebrafish behaviour in three dimensions using a robotic stimulus.Scientific reports · 2018Article
- Escape and surveillance asymmetries in locusts exposed to a Guinea fowl-mimicking robot predator.Scientific reports · 2017Article
- Multiple cues produced by a robotic fish modulate aggressive behaviour in Siamese fighting fishes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish are gaining momentum as a laboratory animal species for the study of anxiety-related disorders in translational research, whereby they serve a fundamental complement to laboratory rodents. Several anxiety-related behavioral paradigms, which rest upon the presentation of live predatorial stimuli, may yield inconsistent results due to fatigue, habituation, or idiosyncratic responses exhibited by the stimulus itself. To overcome these limitations, we designed and manufactured a fully controllable robot inspired by a natural aquatic predator (Indian leaf fish, Nandus nandus) of zebrafish. We report that this robot elicits aversive antipredatorial reactions in a preference test and that data obtained therein correlate with data observed in traditional anxiety- and fear-related tests (light/dark preference and shelter-seeking). Finally, ethanol administration (0.25; 0.50; 1.00%) exerts anxiolytic effects, thus supporting the view that robotic stimuli can be used in the analysis of anxiety-related behaviors in zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.