ArticlePloS one2013
Association of major depressive episode with negative outcomes of tuberculosis treatment.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prevalence and Predictors of Anxiety among Tuberculosis Patients in India: A Systematic Review and Meta-Analysis.Journal of epidemiology and global health · 2026Pooled it
- Pooled it
- Impact of mental disorders on active TB treatment outcomes: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020Pooled it
- Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Silent barriers: psycho-social factors and the hidden risk of medication non-adherence among tuberculosis patients in Mongolia.Journal of clinical tuberculosis and other mycobacterial diseases · 2026Article
- Article
- Article
- Prevalence and predictors of depression in tuberculosis patients in india: a systematic review and meta-analysis.Discover mental health · 2025Review
- Comorbidities and HIV-related factors associated with mental health symptoms and unhealthy substance use among older adults living with HIV in low- and middle-income countries: a cross-sectional study.Journal of the International AIDS Society · 2025Article
- Dual burden of TB and mental ill-health: Prevalence and associated factors of anxiety and depression among TB patients in Gujarat.Journal of family medicine and primary care · 2024Article
- The association between common mental disorders and tuberculosis: a case-control study from Guinea-Bissau.Acta neuropsychiatrica · 2024Article
- Programmatic implementation of depression screening and remote mental health support sessions for persons recently diagnosed with TB in Lima, Peru during the COVID-19 pandemic.Global mental health (Cambridge, England) · 2024Article
- Article
- Article
- Depression, anxiety and medication adherence among tuberculosis patients attending treatment centres in Fako Division, Cameroon: cross-sectional study.BJPsych open · 2023Article
- Influencing Factors of Treatment Outcomes Among Patients with Pulmonary Tuberculosis: A Structural Equation Model Approach.Psychology research and behavior management · 2023Article
- Magnitude of Depression and Associated Factors Among Patients on Tuberculosis Treatment at Public Health Facilities in Harari Regional State, Eastern Ethiopia: Multi-Center Cross-Sectional Study.Neuropsychiatric disease and treatment · 2022Article
- Social Support and Depression Among Pulmonary Tuberculosis Patients in Anhui, China.Journal of multidisciplinary healthcare · 2022Article
- Risk Factors for Depression in Tuberculosis Patients: A Meta-Analysis.Neuropsychiatric disease and treatment · 2022Article
- Mental Health Status and Its Impact on TB Treatment and Its Outcomes: A Scoping Literature Review.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPulmonary tuberculosis (TB) persists an important contributor to the burden of diseases in developing countries. TB control success is based on the patient's compliance to the treatment. Depressive disorders have been negatively associated with compliance of therapeutic schemes for chronic diseases. This study aimed to estimate the significance and magnitude of major depressive episode as a hazard factor for negative outcomes (NO), including abandon or death in patients receiving TB treatment. METHODOLOGY/PRINCIPAL
findingsA longitudinal study was conducted to evaluate the association of major depressive episode (MDE), as measured by a 5-item version of the Center for Epidemiological Studies Depression Scale (CES-D) with NO to TB treatment. Patients with confirmed TB were enrolled before the start of TB treatment. Baseline measurements included socio-demographic variables as well as the CES-D, which was also applied every month until the end of the treatment. Death and treatment default were assessed monthly. Survivor function (SF) for NO according to MDE status (CES-D≥6) at baseline (MDEb) was estimated. Cox's Regression was performed for bivariate analyses as well as for the multivariate model. A total of 325 patients accepted to participate in the study, of which 34 where excluded for diagnosis of MDR-TB. NO was observed in 24 patients (8.2%); 109 (37%) presented MDEb. Statistically significant difference was found on the SF of patients with and without MDEb (0.85 vs. 0.96, p-value = 0.002). The hazard ratio for NO, controlled for age, sex, marital status and instruction level was 3.54 (95%CI 1.43-8.75; p-value = 0.006).
conclusionThe presence of MDE at baseline is associated to NO of TB treatment. Targeting detection and treatment of MDE may improve TB treatment outcomes.
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