ArticlePloS one2013
A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Protocol for dissecting and excising the brain of the Manduca sexta (Lepidoptera: Sphingidae) moth.Journal of insect science (Online) · 2026Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.iScience · 2024Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
- Identification and Pharmacological Characterization of Two Serotonin Type 7 Receptor Isoforms fromInternational journal of molecular sciences · 2022Article
- Serotonergic modulation across sensory modalities.Journal of neurophysiology · 2020Review
- Multiple Biogenic Amine Receptor Types Modulate Spider,Frontiers in physiology · 2018Article
- Intrinsic and Extrinsic Neuromodulation of Olfactory Processing.Frontiers in cellular neuroscience · 2017Review
- Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster.Scientific reports · 2016Article
- The anatomical basis for modulatory convergence in the antennal lobe of Manduca sexta.The Journal of comparative neurology · 2016Article
- Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa. However, the mechanisms underlying neuromodulation are made complex by the diversity of neuromodulatory receptors expressed within a neural network. In this study we begin to examine the receptor basis for serotonergic neuromodulation in the antennal lobe of Manduca sexta. To this end we cloned all four known insect serotonin receptor types from Manduca (the Ms5HTRs). We used phylogenetic analyses to classify the Ms5HTRs and to establish their relationships to other insect serotonin receptors, other insect amine receptors and the vertebrate serotonin receptors. Pharmacological assays demonstrated that each Ms5HTR was selective for serotonin over other endogenous amines and that serotonin had a similar potency at all four Ms5HTRs. The pharmacological assays also identified several agonists and antagonists of the different Ms5HTRs. Finally, we found that the Ms5HT1A receptor was expressed in a subpopulation of GABAergic local interneurons suggesting that the Ms5HTRs are likely expressed heterogeneously within the antennal lobe based on functional neuronal subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.