ArticlePloS one2013
DNA methyltransferase candidate polymorphisms, imprinting methylation, and birth outcome.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review.PloS one · 2018Pooled it
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- Epigenetic studies in children at risk of stunting and their parents in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper.BMJ paediatrics open · 2024Article
- Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity-A Multicenter Portuguese Cohort Study.International journal of molecular sciences · 2023Article
- Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps.Epigenetics · 2022Review
- DNMT1 and DNMT3B gene variants and their association with endometriosis in South Indian women.Molecular biology reports · 2022Article
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- Fetal Membrane Epigenetics.Frontiers in physiology · 2020Review
- Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate withMetabolites · 2019Article
- Association of Polymorphisms in Genes Involved in One-Carbon Metabolism withInternational journal of molecular sciences · 2019Article
- miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring.PloS one · 2019Article
- Article
- Breast cancer risk and imprinting methylation in blood.Clinical epigenetics · 2015Article
- Nutrition, the brain and cognitive decline: insights from epigenetics.European journal of clinical nutrition · 2014Review
- Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.Epigenetics · 2014Article
- Epigenetics and nutritional environmental signals.Integrative and comparative biology · 2014Review
- Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Imprinting genes associated with endometriosis.EXCLI journal · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBirth weight and prematurity are important obstetric outcomes linked to lifelong health. We studied a large birth cohort to look for evidence of epigenetic involvement in birth outcomes.
methodsWe investigated the association between birth weight, length, placental weight and duration of gestation and four candidate variants in 1,236 mothers and 1,073 newborns; DNMT1 (rs2162560), DNMT3A (rs734693), DNMT3B (rs2424913) and DNMT3L (rs7354779). We measured methylation of LINE1 and the imprinted genes, PEG3, SNRPN, and IGF2, in cord blood.
resultsThe minor DNMT3L allele in the baby was associated with higher birth weight (+54 95% CI 10,99 g; p = 0.016), birth length (+0.23 95% CI 0.04,0.42 cm; p = 0.017), placental weight, (+18 95% CI 3,33 g; p = 0.017), and reduced risk of being in the lowest birth weight decile (p = 0.018) or requiring neonatal care (p = 0.039). The DNMT3B minor allele in the mother was associated with an increased risk of prematurity (p = 0.001). Placental size was related to PEG3 (p<0.001) and IGF2 (p<0.001) methylation. Birth weight was related to LINE1 and IGF2 methylation but only at p = 0.052. The risk of requiring neonatal treatment was related to LINE1 (p = 0.010) and SNRPN (p = 0.001) methylation. PEG3 methylation was influenced by baby DNMT3A genotype (p = 0.012) and LINE1 by baby 3B genotype (p = 0.044). Maternal DNMT3L genotype was related to IGF2 methylation in the cord blood but this effect was only seen in carriers of the minor frequency allele (p = 0.050).
conclusionsThe results here suggest that epigenetic processes are linked birth outcome and health in early life. Our emerging understanding of the role of epigenetics in health and biological function across the lifecourse suggests that these early epigenetic events could have longer term implications.
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