ArticlePloS one2013
Selective hepatitis B virus vaccination has reduced hepatitis B virus transmission in the Netherlands.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A systematic review and meta-analysis of sexually transmitted infections and blood-borne viruses in travellers.Journal of travel medicine · 2024Pooled it
- Economic evaluation of HBV vaccination: A systematic review of recent publications (2000-2013).Human vaccines & immunotherapeutics · 2016Pooled it
- Article
- Review
- Antithrombin as a marker of severe acute hepatitis B.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Chronic hepatitis B and C infections in the Netherlands: estimated prevalence in risk groups and the general population.Epidemiology and infection · 2019Article
- Genetic variation of hepatitis B surface antigen among acute and chronic hepatitis B virus infections in The Netherlands.Journal of medical virology · 2018Article
- Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows.PloS one · 2018Article
- Effects of vaccine-acquired polyclonal anti-HBs antibodies on the prevention of HBV infection of non-vaccine genotypes.Journal of gastroenterology · 2017Article
- Article
- Article
- Article
- Ongoing transmission of hepatitis B virus in rural parts of the Netherlands, 2009-2013.PloS one · 2015Article
- Phylogenetic studies of transmission dynamics in generalized HIV epidemics: an essential tool where the burden is greatest?Journal of acquired immune deficiency syndromes (1999) · 2014Review
- Evolutionary genetics of genotype H1 measles viruses in China from 1993 to 2012.The Journal of general virology · 2014Article
- Enigmatic origin of hepatitis B virus: an ancient travelling companion or a recent encounter?World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsIn the Netherlands, a selective hepatitis B virus (HBV) vaccination programme started in 2002 for men having sex with men, drug users, commercial sex workers and heterosexuals with frequent partner changes. We assessed the programme's effectiveness to guide policy on HBV prevention.
methodsWe analysed reports of acute HBV infection in the Netherlands between 2004 and 2010 requesting serum from patients for HBV-genome S- and C-region sequencing. We used coalescence analyses to assess genetic diversity of nonimported genotype-A cases over time.
results1687 patients with acute HBV infection were reported between 2004 and 2010. The incidence of reported acute HBV infection decreased from 1.8 to 1.2 per 100,000 inhabitants, mostly due to a reduction in the number of cases in men who have sex with men. Men were overrepresented among cases with an unknown route of transmission, especially among genotype A2 cases mainly associated with transmission through male homosexual contact. The genetic diversity of nonimported genotype-A strains obtained from men who have sex with men decreased from 2006 onwards, suggesting HBV incidence in this group decreased.
conclusionsThe selective HBV-vaccination programme for behavioural high-risk groups very likely reduced the incidence of HBV infection in the Netherlands mainly by preventing HBV infections in men who have sex with men. A considerable proportion of cases in men who did not report risk behaviour was probably acquired through homosexual contact. Our findings support continuation of the programme, and adopting similar approaches in other countries where HBV transmission is focused in high-risk adults.
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