ArticlePloS one2013
Patient factors influencing the prescribing of lipid lowering drugs for primary prevention of cardiovascular disease in UK general practice: a national retrospective cohort study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- Targeted case finding in the prevention of cardiovascular disease: a stepped wedge cluster randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016 · on this mapTrial
- General practitioners' use of absolute risk versus individual risk factors in cardiovascular disease prevention: an experimental study.BMJ open · 2014Trial
- Trends and inequalities in statin use for the primary and secondary prevention of cardiovascular disease between 2009 and 2021 in England: a series of cross-sectional and cohort studies.BMJ public health · 2026Article
- Lipid management strategies for diabetic patients align with an evidence-based guideline.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Prescribing patterns of statins and associated factors among type 2 diabetes mellitus patients in Africa: A systematic review and meta-analysis.Metabolism open · 2024Article
- Clinical competence, communication ability and adherence to choosing wisely recommendations for lipid reducing drug use in older adults.BMC geriatrics · 2023Article
- Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.European journal of preventive cardiology · 2023Article
- Article
- Long-Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.Journal of the American Heart Association · 2022Article
- Cross-sectional analysis of educational inequalities in primary prevention statin use in UK Biobank.Heart (British Cardiac Society) · 2022Article
- Prevalence and factors associated with lipid-lowering medications use for primary and secondary prevention of cardiovascular diseases among Malaysians: the REDISCOVER study.BMC public health · 2022Article
- Statin Prescription Patterns and Associated Factors Among Patients with Type 2 Diabetes Mellitus Attending Diabetic Clinic at Muhimbili National Hospital, Dar es Salaam, Tanzania.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Multiple Socioeconomic Circumstances and Initiation of Cardiovascular Medication among Ageing Employees.International journal of environmental research and public health · 2021Article
- Impact of multiple cardiovascular medications on mortality after an incidence of ischemic stroke or transient ischemic attack.BMC medicine · 2021Article
- Factors predicting statin prescribing for primary prevention: a historical cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Article
- Guideline Concordance of Statin Treatment Decisions: A Retrospective Cohort Study.Journal of clinical medicine · 2020Article
- Impact of lowering the risk threshold for statin treatment on statin prescribing: a descriptive study in English primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines indicate eligibility for lipid lowering drugs, but it is not known to what extent GPs' follow guidelines in routine clinical practice or whether additional clinical factors systematically influence their prescribing decisions.
methodsA retrospective cohort analysis was undertaken using electronic primary care records from 421 UK general practices. At baseline (May 2008) patients were aged 30 to 74 years, free from cardiovascular disease and not taking lipid lowering drugs. The outcome was prescription of a lipid lowering drug within the next two years. The proportions of eligible and ineligible patients prescribed lipid lowering drugs were reported and multivariable logistic regression models were used to investigate associations between age, sex, cardiovascular risk factors and prescribing.
resultsOf 365,718 patients with complete data, 13.8% (50,558) were prescribed lipid lowering drugs: 28.5% (21,101/74,137) of those eligible and 10.1% (29,457/291,581) of those ineligible. Only 41.7% (21,101/50,558) of those prescribed lipid lowering drugs were eligible. In multivariable analysis prescribing was most strongly associated with increasing age (OR for age ≥ 65 years 4.21; 95% CI 4.05-4.39); diabetes (OR 4.49; 95% CI 4.35-4.64); total cholesterol level ≥ 7 mmol/L (OR 2.20; 95% CI 2.12-2.29); and ≥ 4 blood pressure measurements in the past year (OR 4.24; 95% CI 4.06-4.42). The predictors were similar in eligible and ineligible patients.
conclusionsMost lipid lowering drugs for primary prevention are prescribed to ineligible patients. There is underuse of lipid lowering drugs in eligible patients.
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