ArticlePloS one2013
Context-dependent competition in a model gut bacterial community.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Gut Competition Dynamics of Live Bacterial Therapeutics Are Shaped by Microbiome Complexity, Diet, and Therapeutic Transgenes.bioRxiv : the preprint server for biology · 2025Article
- No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregativeJournal of bacteriology · 2023Article
- Chicken gut microbiome members limit the spread of an antimicrobial resistance plasmid inProceedings. Biological sciences · 2021Article
- Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut.Nature ecology & evolution · 2020Article
- How sample heterogeneity can obscure the signal of microbial interactions.The ISME journal · 2019Review
- Environmental filtering increases with elevation for the assembly of gut microbiota in wild pikas.Microbial biotechnology · 2019Article
- Competition amongVeterinary sciences · 2018Article
- From hairballs to hypotheses-biological insights from microbial networks.FEMS microbiology reviews · 2018Review
- Disentangling complex parasite interactions: Protection against cerebral malaria by one helminth species is jeopardized by co-infection with another.PLoS neglected tropical diseases · 2018Article
- Exposure to Yeast Shapes the Intestinal Bacterial Community Assembly in Zebrafish Larvae.Frontiers in microbiology · 2018Article
- Human Gut Microbiota: Toward an Ecology of Disease.Frontiers in microbiology · 2017Review
- Article
- Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development.The ISME journal · 2016Article
- Bacterial Communities: Interactions to Scale.Frontiers in microbiology · 2016Review
- Ecology of bacteria in the human gastrointestinal tract--identification of keystone and foundation taxa.Microbiome · 2015Article
- Biotic interactions and temporal dynamics of the human gastrointestinal microbiota.The ISME journal · 2015Article
- Impact of a novel protein meal on the gastrointestinal microbiota and the host transcriptome of larval zebrafish Danio rerio.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the ecological processes that generate complex community structures may provide insight into the establishment and maintenance of a normal microbial community in the human gastrointestinal tract, yet very little is known about how biotic interactions influence community dynamics in this system. Here, we use natural strains of Escherichia coli and a simplified model microbiota to demonstrate that the colonization process on the strain level can be context dependent, in the sense that the outcome of intra-specific competition may be determined by the composition of the background community. These results are consistent with previous models for competition between organisms where one competitor has adapted to low resource environments whereas the other is optimized for rapid reproduction when resources are abundant. The genomic profiles of E. coli strains representing these differing ecological strategies provide clues for deciphering the genetic underpinnings of niche adaptation within a single species. Our findings extend the role of ecological theory in understanding microbial systems and the conceptual toolbox for describing microbial community dynamics. There are few, if any, concrete examples of context-dependent competition on a single trophic level. However, this phenomenon can have potentially dramatic effects on which bacteria will successfully establish and persist in the gastrointestinal system, and the principle should be equally applicable to other microbial ecosystems.
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Registered trials
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