ArticlePloS one2013
Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with serotype and disease progression.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Carriage of the JP2 Genotype ofPathogens (Basel, Switzerland) · 2022Article
- Review
- Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022Article
- Genetic Profiling ofPathogens (Basel, Switzerland) · 2019Article
- Tools ofJournal of clinical medicine · 2019Review
- Article
- Effect of total sonicated Aggregatibacter actinomycetemcomitans fragments on gingival stem/progenitor cells.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Dataset of the proteome of purified outer membrane vesicles from the human pathogenData in brief · 2017Article
- Characterization of A. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in Morocco.Clinical oral investigations · 2016Article
- Article
- Occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis in Turkey.Archives of oral biology · 2016Article
- Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT.Frontiers in cellular and infection microbiology · 2016Article
- Article
- Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin.Journal of oral microbiology · 2015Article
- Review
- Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis.Virulence · 2015Review
- Smad2 is involved in Aggregatibacter actinomycetemcomitans-induced apoptosis.Journal of dental research · 2014Article
- Article
- Leukotoxic activity of Aggregatibacter actinomycetemcomitans and periodontal attachment loss.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe cytolethal distending toxin (Cdt) is a highly conserved exotoxin that are produced by a number of Gram negative bacteria, including Aggregatibacter actinomycetemcomitans, and affects mammalian cells by inhibiting cell division and causing apoptosis. A complete cdt-operon is present in the majority of A. actinomycetemcomitans, but the proportion of isolates that lack cdt-encoding genes (A, B and C) varies according to the population studied. The objectives of this study were to examine serotype, Cdt-genotype, and Cdt-activity in isolates of A. actinomycetemcomitans collected from an adolescent West African population and to examine the association between the carrier status of A. actinomycetemcomitans and the progression of attachment loss (AL). MATERIALS AND
methodsA total of 249 A. actinomycetemcomitans isolates from 200 Ghanaian adolescents were examined for serotype and cdt-genotype by PCR. The activity of the Cdt-toxin was examined by DNA-staining of exposed cultured cells and documented with flow cytometry. The periodontal status of the participants was examined at baseline and at a two-year follow-up.
resultsPresence of all three cdt-encoding genes was detected in 79% of the examined A. actinomycetemcomitans isolates. All these isolates showed a substantial Cdt-activity. The two different cdt-genotypes (with and without presence of all three cdt-encoding genes) showed a serotype-dependent distribution pattern. Presence of A. actinomycetemcomitans was significantly associated with progression of AL (OR = 5.126; 95% CI = [2.994-8.779], p<0.001).
conclusionA. actinomycetemcomitans isolated from the Ghanaian adolescents showed a distribution of serotype and cdt-genotype in line with results based on other previously studied populations. Presence of A. actinomycetemcomitans was significantly associated with disease progression, in particular the b serotype, whereas the association with disease progression was not particularly related to cdt-genotype, and Cdt-activity.
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