ArticleInternational journal of tryptophan research : IJTR2013
Role of NAD(+), Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders.
Article in International journal of tryptophan research : IJTR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations.FEBS open bio · 2026Article
- Autophagy-NADFrontiers in molecular biosciences · 2025Review
- Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.Nature communications · 2024Article
- Tryptophan Metabolism and Gut Microbiota: A Novel Regulatory Axis Integrating the Microbiome, Immunity, and Cancer.Metabolites · 2023Review
- Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopment.Brain, behavior, & immunity - health · 2023Article
- NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota.Nutrients · 2023Review
- Article
- The Plasma Levels of 3-Hydroxybutyrate, Dityrosine, and Other Markers of Oxidative Stress and Energy Metabolism in Major Depressive Disorder.Diagnostics (Basel, Switzerland) · 2022Article
- Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats.Microorganisms · 2021Article
- Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway.Psychopharmacology · 2021Article
- Mitochondrial dysfunction: A hidden trigger of autism?Genes & diseases · 2021Review
- The Generalized Adaptation Account of Autism.Frontiers in neuroscience · 2020Article
- Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review.Frontiers in physiology · 2020Review
- MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.Genes & development · 2019Article
- The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids.Frontiers in endocrinology · 2019Review
- Advances in the design of nanomaterial-based electrochemical affinity and enzymatic biosensors for metabolic biomarkers: A review.Mikrochimica acta · 2018Review
- Tryptophan status in autism spectrum disorder and the influence of supplementation on its level.Metabolic brain disease · 2017Article
- A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms.Neuropsychiatric disease and treatment · 2017Article
- Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale.International journal of tryptophan research : IJTR · 2017Review
- Measurement of Serum Superoxide Dismutase and Its Relevance to Disease Intensity Autistic Children.Maedica · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is a pervasive neuro-developmental disorder characterized by impaired social interaction, reduced/absent verbal and non-verbal communication, and repetitive behavior during early childhood. The etiology of this developmental disorder is poorly understood, and no biomarkers have been identified. Identification of novel biochemical markers related to autism would be advantageous for earlier clinical diagnosis and intervention. Studies suggest that oxidative stress-induced mechanisms and reduced antioxidant defense, mitochondrial dysfunction, and impaired energy metabolism (NAD(+), NADH, ATP, pyruvate, and lactate), are major causes of ASD. This review provides renewed insight regarding current autism research related to oxidative stress, mitochondrial dysfunction, and altered tryptophan metabolism in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.