Evidence map›Paper›PMID 23922303›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013

Acute infection induces a metastatic niche: a double menace for cancer patients.

Heath A Smith, Yibin Kang

Abstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. The authors respond to feedback onFrontiers in oncology · 2026
    Article
  2. Cell-cell communication characteristics in breast cancer metastasis.Cell communication and signaling : CCS · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. eLife · 2020
    Article
  8. Far-reaching effects from carbon nanotubes.Nature nanotechnology · 2019
    Article
  9. Remodeling the Microenvironment before Occurrence and Metastasis of Cancer.International journal of biological sciences · 2019
    Review
  10. Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  11. Review
  12. Sensing risk, fearing uncertainty: systems science approach to change.Frontiers in computational neuroscience · 2014
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Heath A SmithDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Yibin Kang

Funding

Metadherin in Metastasis and Chemoresistance of Breast CancerR01CA134519 · NCI · PRINCETON UNIVERSITY · PI KANG, YIBIN · 2008 to 2012
$1.6M
The Role of miRNAs in Epithelial-Mesenchymal Transition and MetastasisR01CA141062 · NCI · PRINCETON UNIVERSITY · PI KANG, YIBIN · 2010 to 2014
$1.6M
NCI NIH HHS R01 CA134519NCI NIH HHS R01 CA141062
6 · The paper itself

Abstract

Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.

Indexed as

Acute Lung InjuryAnimalsHumansLung NeoplasmsReceptors, CXCR4UbiquitinCXCR4 protein, humanReceptors, CXCR4Ubiquitin

Identifiers

PMID23922303
PMCPMC3771332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.