ArticleParasitology research2013
Antiplasmodial activity of ethanolic extracts of some selected medicinal plants from the northwest of Iran.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review.Marine drugs · 2023Review
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Mechanism of action of glycyrrhizin against Plasmodium falciparum.Memorias do Instituto Oswaldo Cruz · 2021Article
- Antioxidant Activity ofMedicines (Basel, Switzerland) · 2018Review
- Antiplasmodial Property ofJournal of arthropod-borne diseases · 2018Article
- Antimalarial evaluation of selected medicinal plant extracts used in Iranian traditional medicine.Iranian journal of basic medical sciences · 2017Article
- Evaluation of Novel α-(Acyloxy)-α-(Quinolin-4-yl) Acetamides as Antiplasmodial Agents.Iranian journal of pharmaceutical research : IJPR · 2017Article
- In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.Malaria journal · 2015Article
- Artemia salina as a model organism in toxicity assessment of nanoparticles.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey.Parasitology research · 2014Article
- In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2-Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives.Iranian journal of parasitologyArticle
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7 authors at 4 institutions in 1 country.
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Abstract
The effectiveness of antimalarial drugs is declining at an ever accelerating rate, with consequent increase in malaria-related morbidity and mortality. The newest antiplasmodial drug from plants is needed to overcome this problem. The aim of this study was to assess antimalarial activity of the ethanolic extracts of 10 different medicinal plants from eight families against Plasmodium falciparum chloroquine-sensitive 3D7 strain. The selection of the hereby studied plants was based on the existing information on their local ethnobotanic history. Plants were dried, powdered, and macerated in a hydroalcoholic solution. Resulting extracts have been assessed for in vitro and in vivo antimalarial and brine shrimp toxicity activities. Of 10 plant species tested, four plants: Althea officinalis L. (Malvaceae), Myrtus communis Linn (Myrtaceae), Plantago major (Plantaginaceae), and Glycyrrhiza glabra L. (Papilionaceae) displayed promising antimalarial activity in vitro (50% inhibitory concentration values of 62.77, 42.18, 40.00, and 13.56 μg/mL, respectively) with no toxicity against brine shrimp larvae. The crude extracts of three active plants, G. glabra, M. communis, and A. officinalis, also significantly reduced parasitemia in vivo in female Swiss albino mice at a dose of 400 mg/kg compared to no treatment. Antiplasmodial activities of extracts of A. officinalis and M. communis are reported for the first time.
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