Trial reportEuropean journal of applied physiology2013
Pain sensitivity is normalized after a repeated bout of eccentric exercise.
Trial report in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02730598 (Determining Efficacy of the Combined Application of Electrical Stimulated Antagonist Contraction During Walking With Sensory TENS for Increasing Strength and Decreasing Pain in Women With Frequent Knee Symptoms), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determining Efficacy of the Combined Application of Electrical Stimulated Antagonist Contraction During Walking With Sensory TENS for Increasing Strength and Decreasing Pain in Women With Frequent Knee Symptoms
Who cites it
14 citing papers in PubMed.
- Interval eccentric cycling : a promising training modality for sedentary people.European journal of applied physiology · 2026Trial
- A Single Bout of Foam Rolling After Nordic Hamstring Exercise Improves Flexibility but Has No Effect on Muscle Stiffness or Functional Muscle Parameters.Medicina (Kaunas, Lithuania) · 2025Trial
- Ipsilateral resistance exercise prevents exercise-induced central sensitization in the contralateral limb: a randomized controlled trial.European journal of applied physiology · 2015Trial
- Predicting pregnancy-related low back pain: a prospective cohort protocol integrating motor control and functional movement tests with pressure pain thresholds.BMC pregnancy and childbirth · 2026Article
- The Neurophysiological Lesion: A Scoping Review.Journal of chiropractic medicine · 2023Article
- The influence of exercise on clinical pain and pain mechanisms in patients with subacromial pain syndrome.European journal of pain (London, England) · 2022Article
- Exercise-induced muscle damage: multi-parametric MRI quantitative assessment.BMC musculoskeletal disorders · 2021Article
- Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation.Frontiers in pharmacology · 2021Article
- Effects of Acupuncture on Delayed-Onset Muscle Soreness: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- The relationship between stiffness and pain following unaccustomed eccentric exercise: the effects of gentle stretch and repeated bout.European journal of applied physiology · 2019Article
- Article
- Spotlight on topographical pressure pain sensitivity maps: a review.Journal of pain research · 2018Review
- Assessment of Muscle Pain Induced by Elbow-Flexor Eccentric Exercise.Journal of athletic training · 2015Article
- Reduced muscle lengthening during eccentric contractions as a mechanism underpinning the repeated-bout effect.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the effect of repeated bouts of eccentric exercise on the nociceptive withdrawal reflex (NWR) threshold, a measure of sensitivity in the spinal nociceptive system.
methodsSixteen healthy students (age 25.7 ± 0.6 years, BMI 24.8 ± 1 kg m(-2)) participated in this randomized, controlled, crossover study. Two identical bouts of high-intensity eccentric exercises were performed on the tibialis anterior muscle 7 days apart. Control sessions involving no exercise were performed 4 weeks apart the exercise sessions. Pressure pain thresholds (PPT) and the NWR threshold were recorded before, immediately after, and 1 day after both bouts of exercise.
resultsPressure pain thresholds decreased significantly at two of the muscle belly sites on the day after initial bout compared with baseline. NWR threshold decreased by 25 ± 4 % immediately after initial bout and by 30 ± 5 % the next day (p < 0.05) as an indication of generalized pain hypersensitivity. On the contrary, no changes were found in both pain thresholds after second bout of eccentric exercise indicating that both localized and generalized pain sensitivity were normalized.
conclusionIn conclusion, this study for the first time documented that an initial bout of unaccustomed high-intensity eccentric exercise, which results in muscle soreness can induce central sensitization. A repeated bout of exercise, however, facilitates inherent protective spinal mechanisms against the development of muscle soreness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.