ArticleBritish journal of cancer2013
Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis.Journal of the National Cancer Institute · 2015Pooled it
- ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population.PloS one · 2019Trial
- Self-monitoring physical activity with a smartphone application in cancer patients: a randomized feasibility study (SMART-trial).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Trial
- Weight gain prior to entry into a weight-loss intervention study among overweight and obese breast cancer survivors.Journal of cancer survivorship : research and practice · 2014Trial
- A novel biclustering algorithm for mining m6A co-methylation patterns based on beta-binomial distribution and data screening strategy.PLoS computational biology · 2026Article
- Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells.Cell death discovery · 2025Article
- Long-term weight change among breast cancer patients treated with chemotherapy: a longitudinal study over 13 years.Breast cancer research : BCR · 2025Article
- Prevalence of Nutritional Risk and Obesity in Mexican Cancer Outpatients.Journal of clinical medicine · 2025Article
- The relation between excess adiposity and breast cancer in women: Clinical implications and management.Critical reviews in oncology/hematology · 2024Review
- Factors associated with weight gain after breast cancer: Results from a community-based survey of Australian women.Breast (Edinburgh, Scotland) · 2023Article
- Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management.Cancers · 2023Review
- Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study.Frontiers in neuroscience · 2021Article
- Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants.EXCLI journal · 2021Article
- N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer ProliferationFrontiers in oncology · 2021Article
- Article
- A Prospective Study of Weight Gain in Women Diagnosed with Early-Stage Invasive Breast Cancer, Ductal CarcinomaJournal of women's health (2002) · 2020Article
- The Identification of Critical mFrontiers in genetics · 2020Article
- The Effects of Adipocytes on the Regulation of Breast Cancer in the Tumor Microenvironment: An Update.Cells · 2019Review
- mMolecular neurobiology · 2019Review
- Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism?International journal of endocrinology · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPost-diagnosis weight gain in breast cancer patients has been associated with increased cancer recurrence and mortality. Our study was designed to identify risk factors for this weight gain and create a predictive model to identify a high-risk population for targeted interventions.
methodsChart review was conducted on 459 breast cancer patients from Northwestern Robert H. Lurie Cancer Centre to obtain weights and body mass indices (BMIs) over an 18-month period from diagnosis. We also recorded tumour characteristics, demographics, clinical factors, and treatment regimens. Blood samples were genotyped for 14 single-nucleotide polymorphisms (SNPs) in fat mass and obesity-associated protein (FTO) and adiponectin pathway genes (ADIPOQ and ADIPOR1).
resultsIn all, 56% of patients had >0.5 kg m(-2) increase in BMI from diagnosis to 18 months, with average BMI and weight gain of 1.9 kg m(-2) and 5.1 kg, respectively. Our best predictive model was a primarily SNP-based model incorporating all 14 FTO and adiponectin pathway SNPs studied, their epistatic interactions, and age and BMI at diagnosis, with area under receiver operating characteristic curve of 0.85 for 18-month weight gain.
conclusionWe created a powerful risk prediction model that can identify breast cancer patients at high risk for weight gain.
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