Evidence map›Paper›PMID 23922105›Full record

ArticleBritish journal of cancer2013

Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: a case-control study in Italy.

M Rossi, V Edefonti, M Parpinel, P Lagiou, M Franchi, M Ferraroni, A Decarli, A Zucchetto, D Serraino, L Dal Maso and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  12. Chemical Composition andNutrients · 2019
    Article
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  14. Prebiotic nut compounds and human microbiota.Critical reviews in food science and nutrition · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

M Rossi1] Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via G. La Masa, 19, 20156 Milan, Italy [2] Department of Clinical Sciences and Community Health, University of Milan, via G. Venezian 1, 20133 Milan, Italy.
V Edefonti
M Parpinel
P Lagiou
M Franchi
M Ferraroni
A Decarli
A Zucchetto
D Serraino
L Dal Maso
E Negri
C La Vecchia
University of Milan · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMario Negri Institute for Pharmacological Research · ITHarvard University · USUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause of their antioxidant and antimutagenic properties, flavonoids may reduce cancer risk. Some flavonoids have antiestrogenic effects that can inhibit the growth and proliferation of endometrial cancer cells.

methodsIn order to examine the relation between dietary flavonoids and endometrial cancer, we analysed data from an Italian case-control study including 454 incident, histologically confirmed endometrial cancers and 908 hospital-based controls. Information was collected through a validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of flavanols, flavanones, flavonols, anthocyanidins, flavones, isoflavones, and proanthocyanidins. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models conditioned on age and study centre and adjusted for major confounding factors.

resultsWomen in the highest quartile category of proanthocyanidins with ≥3 mers vs the first three quartile categories had an OR for endometrial cancer of 0.66 (95% CI=0.48-0.89). For no other class of flavonoids, a significant overall association was found. There was a suggestion of an inverse association for flavanones and isoflavones among women with body mass index <25 kg m(-2), and, for flavanones, among parous or non-users of hormone-replacement therapy women.

conclusionHigh consumption of selected proanthocyanidins may reduce endometrial cancer risk.

Indexed as

Feeding BehaviorAdolescentAdultAgedAnthocyaninsCase-Control StudiesEndometrial NeoplasmsFemaleFlavanonesFlavonesFlavonolsHumansIsoflavonesItalyMiddle AgedProanthocyanidinsAnthocyaninsFlavanonesFlavonesFlavonolsIsoflavonesProanthocyanidins

Identifiers

PMID23922105
PMCPMC3790154
OpenAlexW2049062940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.