ArticleAnnals of internal medicine2013
Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study.
Article in Annals of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 82 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Test the Feasibility and Acceptability of Using a Gluten Sensor Device to Promote Gluten Free Diet Adherence and Quality of Life in Patients With Celiac Disease
Study of the Causes and Consequences of Persistent Villous Atrophy Despite an Intentionally Strict Gluten-free Diet in Celiac Disease Patients - Effect of an Ultra-strict Gluten-free Diet on Persistent Villous Atrophy
Who cites it
82 citing papers in PubMed, 6 syntheses or guidelines pooled it, 259 citations in OpenAlex.
- Colonic neoplasia and celiac disease: A systematic review.World journal of gastroenterology · 2025Pooled it
- Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review.World journal of gastroenterology · 2021Pooled it
- A Call for Research on the Prognostic Role of Follow-Up Histology in Celiac Disease: A Systematic Review.Frontiers in physiology · 2019Pooled it
- Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis.Gastroenterology · 2017Pooled it
- Younger age at diagnosis predisposes to mucosal recovery in celiac disease on a gluten-free diet: A meta-analysis.PloS one · 2017Pooled it
- Guideline
- Text Message Intervention (TEACH) Improves Quality of Life and Patient Activation in Celiac Disease: A Randomized Clinical Trial.The Journal of pediatrics · 2017Trial
- Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Unlocking New Treatment Horizons for Celiac Disease: PRKCD Revealed as a Promising Target through Mendelian RandomizationEndocrine, metabolic & immune disorders drug targets · 2026Article
- Neighborhood Socioeconomic Deprivation Associates with Decreased Serologic Normalization Rates in Pediatric Celiac Disease.The Journal of pediatrics · 2025Article
- Outcomes in Adults with Celiac Disease Following a Gluten-Free Diet.Journal of clinical medicine · 2025Review
- Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025Review
- Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States.Journal of clinical gastroenterology · 2025Article
- Intestinal celiac disease - related autoantibodies.Frontiers in immunology · 2025Review
- Social Adversities Associate with Worse Disease Control in Pediatric Celiac Disease.The Journal of pediatrics · 2025Article
- A Case of Immune Checkpoint Inhibitor-Induced Duodenitis.ACG case reports journal · 2024Article
- Celiac Disease, Gluten Sensitivity, and Diet Management.Current gastroenterology reports · 2024Review
- Digesting gluten with oral endopeptidases to improve the management of celiac disease.World journal of gastroenterology · 2024Article
- Evolution in coeliac disease diagnosis and management.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Exploring factors influencing quality of life variability among individuals with coeliac disease: an online survey.BMJ open gastroenterology · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- SummaryForPatientsIn
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCeliac disease (CD) is associated with an increased risk for lymphoproliferative malignancy (LPM). Whether this risk is affected by the results of follow-up intestinal biopsy, performed to document mucosal healing, is unknown.
objectiveTo examine the association between mucosal healing in CD and subsequent LPM.
designPopulation-based cohort study.
setting28 pathology departments in Sweden. PATIENTS: 7625 patients with CD who had follow-up biopsy after initial diagnosis. MEASUREMENTS: The risk for LPM was compared with that of the general population by using expected rates. The rate of LPM in patients with persistent villous atrophy was compared with that of those with mucosal healing by using Cox regression.
resultsAmong 7625 patients with CD and follow-up biopsy, 3308 (43%) had persistent villous atrophy. The overall risk for LPM was higher than that in the general population (standardized incidence ratio [SIR], 2.81 [95% CI, 2.10 to 3.67]) and was greater among patients with persistent villous atrophy (SIR, 3.78 [CI, 2.71 to 5.12]) than among those with mucosal healing (SIR, 1.50 [CI, 0.77 to 2.62]). Persistent villous atrophy compared with mucosal healing was associated with an increased risk for LPM (hazard ratio [HR], 2.26 [CI, 1.18 to 4.34]). The risk for T-cell lymphoma was increased (HR, 3.51 [CI, 0.75 to 16.34]) but not for B-cell lymphoma (HR, 0.97 [CI, 0.21 to 4.49]). LIMITATION: No data on dietary adherence.
conclusionIncreased risk for LPM in CD is associated with the follow-up biopsy results, with a higher risk among patients with persistent villous atrophy. Follow-up biopsy may effectively stratify patients with CD by risk for subsequent LPM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.