ArticlePancreas2013
Expression of MUC4 mucin is observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas.
Article in Pancreas, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification.Science advances · 2023Article
- Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s).Biochimica et biophysica acta. Reviews on cancer · 2020Review
- Prognostic significance of E-cadherin and ZEB1 expression in intraductal papillary mucinous neoplasm.Oncotarget · 2018Article
- Differences inJournal of carcinogenesis & mutagenesis · 2018Article
- Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity.Cancer medicine · 2016Review
- Pancreatic adenocarcinoma pathology: changing "landscape".Journal of gastrointestinal oncology · 2015Review
- Article
- Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma.International journal of clinical oncology · 2015Article
- MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway.Oncogene · 2015Article
- Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas.World journal of gastroenterology · 2014Review
- Diagnosis of pancreatic neoplasms using a novel method of DNA methylation analysis of mucin expression in pancreatic juice.PloS one · 2014Article
- Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesThis study aimed to examine expression profile of MUC4 in intraductal papillary mucinous neoplasm of the pancreas (IPMN).
methodsWe performed immunohistochemistry (IHC) of MUC4 in 142 IPMNs, with evaluation of the specificity of 2 anti-MUC4 monoclonal antibodies, 8G7 and 1G8, in cancer cell lines.
resultsMonoclonal antibody 8G7 showed a clear immunoreactivity, whereas MAb 1G8 did not show any immunoreactivity, in the Western blotting and IHC for human pancreatic carcinoma cell lines expressing MUC4 messenger RNA. However, IHC signals detected by both monoclonal antibodies were observed in the tissue specimens. The expression rates of MUC4/8G7 detected by MAb 8G7 and MUC4/1G8 detected by MAb 1G8 in the intestinal-type IPMNs were significantly higher than those in the gastric-type IPMNs. In the intestinal-type IPMNs, MUC4/8G7 was expressed mainly in the cytoplasm of the neoplastic cells, whereas MUC4/1G8 was expressed mainly at the cell apexes. Even in the gastric-type IPMNs with rare MUC4 expression in the low-grade dysplasia, both MUC4 expression rates increased when dysplasia advanced.
conclusionsA significantly higher expression of MUC4 in intestinal-type IPMNs than in gastric-type IPMNs will be one of the biomarkers to discriminate between the intestinal-type IPMNs with high malignancy potential from gastric-type IPMNs with low malignancy potential.
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