ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
A computational model of oxygen transport in the cerebrocapillary levels for normal and pathologic brain function.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Grafted Sertoli cells prevent neuronal cell death and memory loss induced by seizures.Metabolic brain disease · 2023Article
- Anti-inflammatory and antioxidative effects of elderberry diet in the rat model of seizure: a behavioral and histological investigation on the hippocampus.Toxicology research · 2023Article
- COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus.Apoptosis : an international journal on programmed cell death · 2022Article
- Simulation of angiogenesis in three dimensions: Application to cerebral cortex.PLoS computational biology · 2021Article
- Microvascular Tissue Engineering-A Review.Biomedicines · 2021Review
- Predicting Vessel Diameter Changes to Up-Regulate Biphasic Blood Flow During Activation in Realistic Microvascular Networks.Frontiers in physiology · 2020Article
- Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function.Frontiers in physiology · 2019Article
- Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey.Critical care (London, England) · 2017Article
- Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope.The journal of physiological sciences : JPS · 2017Article
- The capillary bed offers the largest hemodynamic resistance to the cortical blood supply.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Progression of Diabetic Capillary Occlusion: A Model.PLoS computational biology · 2016Article
- Article
- Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation.Frontiers in computational neuroscience · 2016Review
- Transendothelial Transport and Its Role in Therapeutics.International scholarly research notices · 2014Review
- Curcumin Effects on Memory Impairment and Restoration of Irregular Neuronal Distribution in the Hippocampal CA1 Region After Global Cerebral Ischemia in Male Rats.Basic and clinical neuroscienceArticle
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2 authors.
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Abstract
The oxygen exchange and correlation between the cerebral blood flow (CBF) and cerebral metabolic rate of oxygen consumption (CMRO2) in the cortical capillary levels for normal and pathologic brain functions remain the subject of debate. A 3D realistic mesoscale model of the cortical capillary network (non-tree like) is constructed using a random Voronoi tessellation in which each edge represents a capillary segment. The hemodynamics and oxygen transport are numerically simulated in the model, which involves rheological laws in the capillaries, oxygen diffusion, and non-linear binding of oxygen to hemoglobin, respectively. The findings show that the cerebral hypoxia due to a significant decreased perfusion (as can occur in stroke) can be avoided by a moderate reduction in oxygen demand. Oxygen extraction fraction (OEF) can be an important indicator for the brain oxygen metabolism under normal perfusion and misery-perfusion syndrome (leading to ischemia). The results demonstrated that a disproportionately large increase in blood supply is required for a small increase in the oxygen demand, which, in turn, is strongly dependent on the resting OEF. The predicted flow-metabolism coupling in the model supports the experimental studies of spatiotemporal stimulations in humans by positron emission tomography and functional magnetic resonance imaging.
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