Evidence map›Paper›PMID 23921796›Full record

ReviewMolecules (Basel, Switzerland)2013

Strategies for optimizing water-exchange rates of lanthanide-based contrast agents for magnetic resonance imaging.

Buddhima N Siriwardena-Mahanama, Matthew J Allen

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Crystal Structures of DOTMA Chelates from CeChemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Article
  7. Review
  8. Article
  9. Fluorinated EuChemical science · 2017
    Article
  10. Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017
    Article
  11. Aqueous Lanthanide Chemistry in Asymmetric Catalysis and Magnetic Resonance Imaging.Synlett : accounts and rapid communications in synthetic organic chemistry · 2016
    Article
  12. Article
  13. Article
  14. Article
  15. Basic MR relaxation mechanisms and contrast agent design.Journal of magnetic resonance imaging : JMRI · 2015
    Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Buddhima N Siriwardena-MahanamaDepartment of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Matthew J Allen
Wayne State University · US

Funding

Increasing the Utility of Contrast Agents for MRIR00EB007129 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2008 to 2010
$746k
NIBIB NIH HHS R00 EB007129NIBIB NIH HHS R00EB007129
6 · The paper itself

Abstract

This review describes recent advances in strategies for tuning the water-exchange rates of contrast agents for magnetic resonance imaging (MRI). Water-exchange rates play a critical role in determining the efficiency of contrast agents; consequently, optimization of water-exchange rates, among other parameters, is necessary to achieve high efficiencies. This need has resulted in extensive research efforts to modulate water-exchange rates by chemically altering the coordination environments of the metal complexes that function as contrast agents. The focus of this review is coordination-chemistry-based strategies used to tune the water-exchange rates of lanthanide(III)-based contrast agents for MRI. Emphasis will be given to results published in the 21st century, as well as implications of these strategies on the design of contrast agents.

Indexed as

Magnetic Resonance ImagingContrast MediaCoordination ComplexesGadoliniumHumansLanthanoid Series ElementsWaterContrast MediaCoordination ComplexesGadoliniumLanthanoid Series ElementsWater

Identifiers

PMID23921796
PMCPMC3775326
OpenAlexW1974803514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.