SynthesisAIDS (London, England)2013
Hepatitis C virus/HIV coinfection and responses to initial antiretroviral treatment.
Synthesis in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Unsuppressed HIV viral load among people living with HIV by exposure category in British Columbia, Canada from 2005 to 2020: a population-based cohort study.BMC global and public health · 2025Article
- Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models.Scientific reports · 2022Article
- Hepatitis C Virus Treatment Status and Barriers among Patients in Methadone Maintenance Treatment Clinics in Guangdong Province, China: A Cross-Sectional, Observational Study.International journal of environmental research and public health · 2019Observational
- Observational
- HIV and viral hepatitis coinfection analysis using surveillance data from 15 US states and two cities.Epidemiology and infection · 2018Article
- Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy.AIDS (London, England) · 2018Article
- Article
- Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Antiretroviral therapy and liver disease progression in HIV and hepatitis C co-infected patients: a systematic review and meta-analysis.Hepatology, medicine and policy · 2016Article
- Hepatitis C in human immunodeficiency virus co-infected individuals: Is this still a "special population"?World journal of hepatology · 2015Review
- Full Viral Suppression, Low-Level Viremia, and Quantifiable Plasma HIV-RNA at the End of Pregnancy in HIV-Infected Women on Antiretroviral Treatment.AIDS research and human retroviruses · 2015Observational
- HIV and viral hepatitis co-infection in New York City, 2000-2010: prevalence and case characteristics.Epidemiology and infection · 2015Article
- Finding meaning in life while living with HIV: validation of a novel HIV meaningfulness scale among HIV-infected participants living in Tennessee.BMC psychology · 2015Article
- Rate and determinants of residual viremia in multidrug-experienced patients successfully treated with raltegravir-based regimens.AIDS research and human retroviruses · 2015Article
- Hepatitis C virus infection in the human immunodeficiency virus infected patient.World journal of gastroenterology · 2014Review
- HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study.AIDS research and therapy · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo explore the relationship between hepatitis C virus (HCV)/HIV coinfection and responses to initial antiretroviral treatment (ART).
methodsFour AIDS Clinical Trials Group HIV treatment studies' data were combined to compare initial ART responses between HCV/HIV-coinfected and HIV-monoinfected patients as evaluated by virologic failure, CD4 cell measures, occurrence of AIDS/death and grade 3/4 safety events, using Kaplan-Meier estimates and proportional hazard, regression and mixed effects models, adjusting for baseline covariates.
resultsOf the 3041 included participants, 81% were men, 19% had prior history of AIDS, the median (25th, 75th percentile) baseline HIV RNA was 4.72 (4.38-5.18) log10 copies/ml, and the median (25th, 75th percentile) baseline CD4 cell count was 216.0 (76.5-327.0) cells/μl. The 279 HCV/HIV-coinfected individuals were older (44 vs. 37 years), more likely to be black non-Hispanic (47 vs. 36%), and previous/current intravenous drug user (52 vs. 5%) than the 2762 HIV-monoinfected patients (all P values <0.001). HCV/HIV coinfection was associated with earlier virologic failure, hazard ratio (95% confidence interval): 1.43 (1.07-1.91); smaller mean CD4 cell increase and CD4% increase [-33.8 (-52.2 to -15.4) cells/μl and -1.16% (-1.43 to -0.89%), respectively] over a median of 132 weeks of follow-up; earlier occurrence of grade 3/4 safety event, hazard ratio 1.51 (1.26-1.81); and increased AIDS/mortality, hazard ratio 2.10 (1.31-3.37). Treatment effects comparing antiretroviral regimens were not significantly different by HCV/HIV coinfection status.
conclusionHCV/HIV coinfection is associated with attenuated response to ART. Results support earlier initiation of HIV therapy and increased monitoring of those initiating ART with HCV/HIV coinfection.
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