Evidence map›Paper›PMID 23921460›Full record

ReviewVirulence2013

Adherence and uptake of Francisella into host cells.

G Brett Moreau, Barbara J Mann

Open access · goldAbstract readReview
In one paragraph

Review in Virulence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Frontiers in cellular and infection microbiology · 2023
    Article
  2. Nucleolin: a cell portal for viruses, bacteria, and toxins.Cellular and molecular life sciences : CMLS · 2022
    Review
  3. Microorganisms · 2020
    Review
  4. The Early Dendritic Cell Signaling Induced by VirulentMolecular & cellular proteomics : MCP · 2018
    Article
  5. Article
  6. Isolation ofFrontiers in cellular and infection microbiology · 2017
    Article
  7. Frontiers in cellular and infection microbiology · 2017
    Article
  8. Importance of Metabolic Adaptations inFrontiers in cellular and infection microbiology · 2017
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Modeling early events in Francisella tularensis pathogenesis.Frontiers in cellular and infection microbiology · 2014
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

G Brett MoreauDepartment of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville, VA USA.
Barbara J MannDepartment of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville, VA USA; Department of Medicine; Division of Infectious Diseases and International Health; University of Virginia; Charlottesville, VA USA.
Charlottesville Medical Research · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI055432
6 · The paper itself

Abstract

Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host cells are not well characterized, and little is known about bacterial factors that promote these processes. This review highlights our current understanding of Francisella attachment and internalization into host cells. In particular, we emphasize the host cell types Francisella has been shown to interact with, as well as specific receptors and signaling processes involved in the internalization process. This review will shed light on gaps in our current understanding and future areas of investigation.

Indexed as

Bacterial AdhesionEndocytosisAnimalsFrancisella tularensisHumansadherenceattachmentFrancisella tularensisinternalizationLVSnovicida

Identifiers

PMID23921460
PMCPMC3925714
OpenAlexW2022272990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.