ArticleNeuroImage2013
Diffusion MRI of the developing cerebral cortical gray matter can be used to detect abnormalities in tissue microstructure associated with fetal ethanol exposure.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
- Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences.NeuroImage · 2025Article
- Intimate partner violence perpetration among veterans: associations with neuropsychiatric symptoms and limbic microstructure.Frontiers in neurology · 2024Article
- High-resolution imaging in studies of alcohol effect on prenatal development.Advances in drug and alcohol research · 2023Article
- Association of War Zone-Related Stress With Alterations in Limbic Gray Matter Microstructure.JAMA network open · 2022Article
- Pilot Study on Analysis of Electroencephalography Signals from Children with FASD with the Implementation of Naive Bayesian Classifiers.Sensors (Basel, Switzerland) · 2021Article
- Alterations in the whole brain network organization after prenatal ethanol exposure.The European journal of neuroscience · 2020Article
- Mild traumatic brain injury impacts associations between limbic system microstructure and post-traumatic stress disorder symptomatology.NeuroImage. Clinical · 2020Article
- In vivo high-resolution diffusion tensor imaging of the developing neonatal rat cortex and its relationship to glial and dendritic maturation.Brain structure & function · 2019Article
- Alcohol Use in Pregnancy.Clinical obstetrics and gynecology · 2019Review
- Detecting Neurodevelopmental Effects of Early-Gestation Ethanol Exposure: A Nonhuman Primate Model of Ethanol Drinking During Pregnancy.Alcoholism, clinical and experimental research · 2019Article
- Using diffusion anisotropy to study cerebral cortical gray matter development.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Effects of Early Alcohol Exposure on Functional Organization and Microstructure of a Visual-Tactile Integrative Circuit.Alcoholism, clinical and experimental research · 2018Article
- The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice.Behavioural brain research · 2018Article
- Differential microstructural alterations in rat cerebral cortex in a model of chronic mild stress depression.PloS one · 2018Article
- Novel Detection of Placental Insufficiency by Magnetic Resonance Imaging in the Nonhuman Primate.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- First trimester alcohol exposure alters placental perfusion and fetal oxygen availability affecting fetal growth and development in a non-human primate model.American journal of obstetrics and gynecology · 2017Article
- Folding, But Not Surface Area Expansion, Is Associated with Cellular Morphological Maturation in the Fetal Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development.Vitamins and hormones · 2017Review
- Reduced glutamate in white matter of male neonates exposed to alcohol in utero: a (1)H-magnetic resonance spectroscopy study.Metabolic brain disease · 2016Article
- 3D structure tensor analysis of light microscopy data for validating diffusion MRI.NeuroImage · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Fetal alcohol spectrum disorders (FASDs) comprise a wide range of neurological deficits that result from fetal exposure to ethanol (EtOH), and are the leading cause of environmentally related birth defects and mental retardation in the western world. One aspect of diagnostic and therapeutic intervention strategies that could substantially improve our ability to combat this significant problem would be to facilitate earlier detection of the disorders within individuals. Light microscopy-based investigations performed by several laboratories have previously shown that morphological development of neurons within the early-developing cerebral cortex is abnormal within the brains of animals exposed to EtOH during fetal development. We and others have recently demonstrated that diffusion MRI can be of utility for detecting abnormal cellular morphological development in the developing cerebral cortex. We therefore assessed whether diffusion tensor imaging (DTI) could be used to distinguish the developing cerebral cortices of ex vivo rat pup brains born from dams treated with EtOH (EtOH; 4.5 g/kg, 25%) or calorie-matched quantities of maltose/dextrin (M/D) throughout gestation. Water diffusion and tissue microstructure were investigated using DTI (fractional anisotropy, FA) and histology (anisotropy index, AI), respectively. Both FA and AI decreased with age, and were higher in the EtOH than the M/D group at postnatal ages (P)0, P3, and P6. Additionally, there was a significant correlation between FA and AI measurements. These findings provide evidence that disruptions in cerebral cortical development induced by EtOH exposure can be revealed by water diffusion anisotropy patterns, and that these disruptions are directly related to cerebral cortical differentiation.
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