Trial reportEpidemiology and infection2014
Application of an integrated outbreak management plan for the control of leptospirosis in dairy cattle herds.
Trial report in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prevalence of Anti-Leptospira Antibodies in Bovines (2018-2023) and Reported Serovars and Serogroups-A Systematic Review With Meta-Analysis.Veterinary medicine and science · 2025Pooled it
- A systematic review of leptospirosis on dogs, pigs, and horses in Latin America.Tropical animal health and production · 2017Pooled it
- A systematic review on the microscopic agglutination test seroepidemiology of bovine leptospirosis in Latin America.Tropical animal health and production · 2016Pooled it
- A Scoping Review of Antimicrobial Therapy inAnimals : an open access journal from MDPI · 2025Review
- Addressing the burden of leptospirosis in Africa.Tropical diseases, travel medicine and vaccines · 2025Review
- How Is Bovine Genital Leptospirosis Diagnosed Under Field Conditions?Animals : an open access journal from MDPI · 2025Article
- Describing diagnosis (MAT + PCR) and control (vaccine + streptomycin sulfate) of a leptospirosis outbreak in dairy cows with reproductive disorders.Animal reproduction · 2025Article
- The role of asymptomatic cattle for leptospirosis dynamics in a herd with imperfect vaccination.Scientific reports · 2024Article
- The Role of Transplacental Infection inMicroorganisms · 2024Article
- Bovine Genital Leptospirosis: An Update of This Important Reproductive Disease.Animals : an open access journal from MDPI · 2024Review
- Seroprevalence of Equine Leptospirosis in the State of Goiás, Brazil.Veterinary sciences · 2023Article
- Article
- Bovine Leptospirosis in Caatinga Biome, Brazil: New Insights into Diagnosis and Epidemiology.Tropical medicine and infectious disease · 2023Article
- Global Seropositivity of Swine Leptospirosis: Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2023Review
- The Efficacy of Vaccination in the Prevention of Renal and Genital Leptospirosis in Experimentally Infected Sheep.Tropical medicine and infectious disease · 2022Article
- Seroprevalence and risk factors for Leptospira spp. in small ruminants of semi-arid zone in northeastern Colombia.Tropical animal health and production · 2021Article
- Strategies of the control of an outbreak of leptospiral infection in dairy cattle in Northeastern Brazil.Tropical animal health and production · 2019Article
- Detection of bovine carriers of Leptospira by serological, bacteriological, and molecular tools.Tropical animal health and production · 2018Article
- Is Leptospira able to survive in raw milk? Study on the inactivation at different storage times and temperatures.Folia microbiologica · 2016Article
- A multilocus variable number tandem repeat analysis assay provides high discrimination for genotyping Leptospira santarosai strains.Journal of medical microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryTwo outbreaks of Leptospira borgpetersenii serovar Hardjo infection in dairy cattle herds were managed through the application of enhanced biosecurity measures, whole-herd antibiotic treatment and vaccination. Micro-agglutination test antibody titres were determined in paired serum samples at 3 weeks (T1: n = 125, 97% seropositivity, median 800, range 100-12 800) and 24 weeks (T2: n = 110, 88% seropositivity, median 200, range 100-6400) after vaccination and studied in relation to cows' age, herd of origin and sampling time. From T1 to T2, vaccine-elicited antibody titres decreased by 84·7% (95% CI 76·2-90·1). Consistent with increasing immunocompetence in calves (aged <12 months) and immunosenescence in adult cows (aged >36 months) associated with ageing, antibody titres correlated positively with calves' age and negatively with adult cows' age. No cow had cultivable, (histo)pathologically detectable and/or PCR-detectable leptospires in urine or kidney samples after treatment and vaccination. Vaccination together with proper biosecurity measures and chemoprophylaxis are an affordable insurance to control bovine leptospirosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.