ArticleIET systems biology2013
Design of synthetic biological logic circuits based on evolutionary algorithm.
Article in IET systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- GCAD: A Computational Framework for Mammalian Genetic Program Computer-Aided Design.ACS synthetic biology · 2026Article
- GCAD: a Computational Framework for Mammalian Genetic Program Computer-Aided Design.bioRxiv : the preprint server for biology · 2025Article
- Synthesis of control unit for future biocomputer.Journal of biological engineering · 2018Article
- Design of dynamic genetic memory.IET systems biology · 2017Article
- Constructing an integrated genetic and epigenetic cellular network for whole cellular mechanism using high-throughput next-generation sequencing data.BMC systems biology · 2016Article
- Implementation of a genetic logic circuit: bio-register.Systems and synthetic biology · 2015Article
- SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology.Scientific reports · 2015Article
- Synthesizing genetic sequential logic circuit with clock pulse generator.BMC systems biology · 2014Article
- Synthesising periodic triggering signals with genetic oscillators.IET systems biology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The construction of an artificial biological logic circuit using systematic strategy is recognised as one of the most important topics for the development of synthetic biology. In this study, a real-structured genetic algorithm (RSGA), which combines general advantages of the traditional real genetic algorithm with those of the structured genetic algorithm, is proposed to deal with the biological logic circuit design problem. A general model with the cis-regulatory input function and appropriate promoter activity functions is proposed to synthesise a wide variety of fundamental logic gates such as NOT, Buffer, AND, OR, NAND, NOR and XOR. The results obtained can be extended to synthesise advanced combinational and sequential logic circuits by topologically distinct connections. The resulting optimal design of these logic gates and circuits are established via the RSGA. The in silico computer-based modelling technology has been verified showing its great advantages in the purpose.
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Registered trials
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