ArticleJournal of the American Chemical Society2013
Antifouling glycocalyx-mimetic peptoids.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 135 citations in OpenAlex.
- Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces.ACS nano · 2024Article
- Factors influencing initial bacterial adhesion to antifouling surfaces studied by single-cell force spectroscopy.iScience · 2024Article
- Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications.Polymers · 2022Article
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- A sandcastle worm-inspired strategy to functionalize wet hydrogels.Nature communications · 2021Article
- Highly selective and antifouling electrochemical biosensors for sensitive MicroRNA assaying based on conducting polymer polyaniline functionalized with zwitterionic peptide.Analytical and bioanalytical chemistry · 2021Article
- Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part I: Molecular Basis of Biofilm Recalcitrance. Passive Anti-Biofouling Nanocoatings.Nanomaterials (Basel, Switzerland) · 2020Review
- The design and development of short peptide-based novel smart materials to prevent fouling by the formation of non-toxic and biocompatible coatings.RSC advances · 2020Article
- Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces.International journal of molecular sciences · 2020Review
- Elucidating the Ordering in Self-Assembled Glycocalyx Mimicking Supramolecular Copolymers in Water.Journal of the American Chemical Society · 2019Article
- A nonfouling voltammetric immunosensor for the carcinoembryonic antigen based on the use of polyaniline nanowires wrapped with hyaluronic acid.Mikrochimica acta · 2018Article
- Synthesis and Mass Spectrometry Analysis of Oligo-peptoids.Journal of visualized experiments : JoVE · 2018Article
- Sulfated glycopeptide nanostructures for multipotent protein activation.Nature nanotechnology · 2017Article
- Anisotropic surface functionalization of Au nanorods driven by molecular architecture and curvature effects.Faraday discussions · 2016Article
- What is the role of curvature on the properties of nanomaterials for biomedical applications?Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Modulation of Protein Fouling and Interfacial Properties at Carbon Surfaces via Immobilization of Glycans Using Aryldiazonium Chemistry.Scientific reports · 2016Article
- Fragmentation Patterns and Mechanisms of Singly and Doubly Protonated Peptoids Studied by Collision Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The glycocalyx of the cell is composed of highly hydrated saccharidic groups conjugated to protein and lipid cores. Although components of the glycocalyx are important in cell-cell interactions and other specific biological recognition events, a fundamental role of the glycocalyx is the inhibition of nonspecific interactions at the cell surface. Inspired by glycoproteins present in the glycocalyx, we describe a new class of synthetic antifouling polymer composed of saccharide containing N-substituted polypeptide (glycopeptoid). Grafting of glycopeptoids to a solid surface resulted in a biomimetic shielding layer that dramatically reduced nonspecific protein, fibroblast, and bacterial cell attachment. All-atom molecular dynamics simulation of grafted glycopeptoids revealed an aqueous interface enriched in highly hydrated saccharide residues. In comparison to saccharide-free peptoids, the interfacial saccharide residues of glycopeptoids formed a higher number of hydrogen bonds with water molecules. Moreover, these hydrogen bonds displayed a longer persistence time, which we believe contributed to fouling resistance by impeding interactions with biomolecules. Our findings suggest that the fouling resistance of glycopeptoids can be explained by the presence of both a 'water barrier' effect associated with the hydrated saccharide residues as well as steric hindrance from the polymer backbone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.