Trial reportInhalation toxicology2013
The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study.
Trial report in Inhalation toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exposure to PM2.5 via vascular endothelial growth factor relationship: Meta-analysis.PloS one · 2018Pooled it
- Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures.Hypertension (Dallas, Tex. : 1979) · 2015Trial
- Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: a controlled human exposure study.Environmental health perspectives · 2015Trial
- Exposure to air pollution and cardiovascular risk in young children - a pilot project.Pediatric research · 2024Article
- Review
- Decoding Physical and Cognitive Impacts of Particulate Matter Concentrations at Ultra-Fine Scales.Sensors (Basel, Switzerland) · 2022Article
- Environmental exposure to volatile organic compounds is associated with endothelial injury.Toxicology and applied pharmacology · 2022Article
- Air Pollution Exposure Induces Vascular Injury and Hampers Endothelial Repair by Altering Progenitor and Stem Cells Functionality.Frontiers in cell and developmental biology · 2022Review
- Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity.American journal of physiology. Heart and circulatory physiology · 2021Review
- Probucol protects circulating endothelial progenitor cells from ambient PMExperimental and therapeutic medicine · 2018Article
- Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis.American journal of physiology. Heart and circulatory physiology · 2016Article
- Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells.Journal of cellular and molecular medicine · 2016Review
- Using Machine Learning to Estimate Global PM2.5 for Environmental Health Studies.Environmental health insights · 2015Article
- Ambient fine particulate matter induces apoptosis of endothelial progenitor cells through reactive oxygen species formation.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015Article
- Estimating the global abundance of ground level presence of particulate matter (PM2.5).Geospatial health · 2014Article
- The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells.Inhalation toxicology · 2014Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
contextFine particulate matter (PM) air pollution has been associated with alterations in circulating endothelial progenitor cell (EPC) levels, which may be one mechanism whereby exposures promote cardiovascular diseases. However, the impact of coarse PM on EPCs is unknown.
objectiveWe aimed to determine the effect of acute exposure to coarse concentrated ambient particles (CAP) on circulating EPC levels.
methodsThirty-two adults (25.9 ± 6.6 years) were exposed to coarse CAP (76.2 ± 51.5 μg m(-3)) in a rural location and filtered air (FA) for 2 h in a randomized double-blind crossover study. Peripheral venous blood was collected 2 and 20 h post-exposures for circulating EPC (n = 21), white blood cell (n = 24) and vascular endothelial growth factor (VEGF) (n = 16-19) levels. The changes between exposures were compared by matched Wilcoxon signed-rank tests.
resultsCirculating EPC levels were elevated 2 [108.29 (6.24-249.71) EPC mL(-1); median (25th-75th percentiles), p = 0.052] and 20 h [106.86 (52.91-278.35) EPC mL(-1), p = 0.008] post-CAP exposure compared to the same time points following FA [38.47 (0.00-84.83) and 50.16 (0.00-104.79) EPC mL(-1)]. VEGF and white blood cell (WBC) levels did not differ between exposures.
conclusionsBrief inhalation of coarse PM from a rural location elicited an increase in EPCs that persisted for at least 20 h. The underlying mechanism responsible may reflect a systemic reaction to an acute "endothelial injury" and/or a circulating EPC response to sympathetic nervous system activation.
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