ReviewJournal of neuroendocrinology2013
Epigenetic contributions to hormonally-mediated sexual differentiation of the brain.
Review in Journal of neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes.Neurology · 2025Article
- Androgen receptor alpha deficiency impacts aromatase expression in the female cichlid brain.Royal Society open science · 2024Article
- Sex and Brain: The Role of Sex Chromosomes and Hormones in Brain Development and Parkinson's Disease.Cells · 2023Review
- Maternal occupational exposure to chemicals and child cognitive function.Pediatric research · 2022Article
- An intergenerational androgenic mechanism of female intrasexual competition in the cooperatively breeding meerkat.Nature communications · 2021Article
- Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.Nature communications · 2021Article
- Emerging Roles of Epigenetics in the Control of Reproductive Function: Focus on Central Neuroendocrine Mechanisms.Journal of the Endocrine Society · 2021Review
- Molecular omics resources should require sex annotation: a call for action.Nature methods · 2021Article
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors.Frontiers in neuroscience · 2021Review
- The Prenatal Hormone Milieu in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
- The Resistance ofAntioxidants (Basel, Switzerland) · 2020Article
- Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women.Foods (Basel, Switzerland) · 2020Article
- Androgens and the developing hippocampus.Biology of sex differences · 2020Review
- The Emerging Role of Chromatin Remodeling Factors in Female Pubertal Development.Neuroendocrinology · 2019Review
- Genome-wide methylation study of whole blood cells DNA in men with congenital hypopituitarism disease.International journal of molecular medicine · 2019Article
- Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?Endocrine · 2018Review
- Hypothalamic epigenetics driving female puberty.Journal of neuroendocrinology · 2018Review
- Are endocrine disrupting compounds environmental risk factors for autism spectrum disorder?Hormones and behavior · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It has been long established that hormones exert enduring influences on the developing brain that direct the reproductive response in adulthood, although the cellular mechanisms by which organisational effects are maintained have not been determined satisfactorily. Recent interest in epigenetic modifications to the nervous system has highlighted the potential for hormone-induced changes to the genome that could endure for the lifespan but not be transmitted to the next generation. Preliminary evidence suggests that this is indeed possible because sex differences in the histone code and in the methylation of CpGs in the promoters of specific genes have been identified and, at times, functionally correlated with behaviour. The present review provides an overview of epigenetic processes and discusses the current state-of-the-art, and also identifies future directions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.