Evidence map›Paper›PMID 23919179›Full record

ArticleBiology2012

Recruitment of transcription complexes to enhancers and the role of enhancer transcription.

Jared S Stees, Fred Varn, Suming Huang, John Strouboulis, Jörg Bungert

Open access · goldAbstract read
In one paragraph

Article in Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Enhancer RNA (eRNA) in Human Diseases.International journal of molecular sciences · 2022
    Review
  2. Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs.International journal of molecular sciences · 2020
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jared S SteesDepartment of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
Fred Varn
Suming Huang
John Strouboulis
Jörg Bungert
University of Florida · USAlexander Fleming Biomedical Sciences Research Center · GR

Funding

STRUCTURE/FUNCTION OF THE HUMAN B-GLOBIN LCRR01DK052356 · NIDDK · UNIVERSITY OF FLORIDA · PI BUNGERT, JORG · 1997 to 2017
$4.7M
Functional proteomics in differentiating erythroid cellsR01DK083389 · NIDDK · UNIVERSITY OF FLORIDA · PI BUNGERT, JORG, STROUBOULIS, IOANNIS JOHN · 2010 to 2013
$1.1M
NIDDK NIH HHS R01 DK052356NIDDK NIH HHS R01 DK083389
6 · The paper itself

Abstract

Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

Indexed as

enhancerlocus control regionloopingRNAtranscriptiontranscription factor

Identifiers

PMID23919179
PMCPMC3732451
OpenAlexW2113330652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.