ArticleEcology and evolution2013
Alternative forms for genomic clines.
Article in Ecology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Genomic signatures of reproductive isolation are decoupled from floral divergence in a long-standing hybrid zone.bioRxiv : the preprint server for biology · 2026Article
- Comparative Genomic Analysis of Co-Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation.Molecular ecology · 2025Article
- The Shapes of Clines and Wavefronts.Molecular ecology · 2025Review
- Repeatable Selection on Large Ancestry Blocks in an Avian Hybrid Zone.Molecular biology and evolution · 2025Article
- Hybrid zones in the European Alps impact the phylogeography of alpine vicariant willow species (Frontiers in plant science · 2025Article
- A Next Generation of Hierarchical Bayesian Analyses of Hybrid Zones Enables Model-Based Quantification of Variation in Introgression in R.Ecology and evolution · 2024Article
- Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones.Molecular biology and evolution · 2024Article
- Understanding species limits through the formation of phylogeographic lineages.Ecology and evolution · 2024Article
- Genetic admixture drives climate adaptation in the bank vole.Communications biology · 2024Article
- Experimental evolution of hybrid populations to identify Dobzhansky-Muller incompatibility loci.Ecology and evolution · 2024Article
- Mapping restricted introgression across the genomes of admixed indigenous African cattle breeds.Genetics, selection, evolution : GSE · 2023Article
- Quantitative Analyses of Coupling in Hybrid Zones.Cold Spring Harbor perspectives in biology · 2023Review
- Genomic clines across the species boundary between a hybrid pine and its progenitor in the eastern Tibetan Plateau.Plant communications · 2023Article
- Weak coupling among barrier loci and waves of neutral and adaptive introgression across an expanding hybrid zone.Evolution; international journal of organic evolution · 2021Article
- ClineHelpR: an R package for genomic cline outlier detection and visualization.BMC bioinformatics · 2021Article
- A narrow window for geographic cline analysis using genomic data: Effects of age, drift, and migration on error rates.Molecular ecology resources · 2021Article
- Spatial population genetics in heavily managed species: Separating patterns of historical translocation from contemporary gene flow in white-tailed deer.Evolutionary applications · 2021Article
- Genomic evidence of recent hybridization between sea turtles at Abrolhos Archipelago and its association to low reproductive output.Scientific reports · 2020Article
- Environment-dependent introgression from Quercus dentata to a coastal ecotype of Quercus mongolica var. crispula in northern Japan.The New phytologist · 2020Article
- Hybridization drives genetic erosion in sympatric desert fishes of western North America.Heredity · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding factors regulating hybrid fitness and gene exchange is a major research challenge for evolutionary biology. Genomic cline analysis has been used to evaluate alternative patterns of introgression, but only two models have been used widely and the approach has generally lacked a hypothesis testing framework for distinguishing effects of selection and drift. I propose two alternative cline models, implement multivariate outlier detection to identify markers associated with hybrid fitness, and simulate hybrid zone dynamics to evaluate the signatures of different modes of selection. Analysis of simulated data shows that previous approaches are prone to false positives (multinomial regression) or relatively insensitive to outlier loci affected by selection (Barton's concordance). The new, theory-based logit-logistic cline model is generally best at detecting loci affecting hybrid fitness. Although some generalizations can be made about different modes of selection, there is no one-to-one correspondence between pattern and process. These new methods will enhance our ability to extract important information about the genetics of reproductive isolation and hybrid fitness. However, much remains to be done to relate statistical patterns to particular evolutionary processes. The methods described here are implemented in a freely available package "HIest" for the R statistical software (CRAN; http://cran.r-project.org/).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.