ArticleIndian journal of sexually transmitted diseases and AIDS2013
Herpes genitalis - Topical zinc sulfate: An alternative therapeutic and modality.
Article in Indian journal of sexually transmitted diseases and AIDS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Association between dietary zinc intake and herpes simplex virus seropositivity in U.S. adults: a cross-sectional study.BMC infectious diseases · 2026Article
- Review
- Trace element zinc and skin disorders.Frontiers in medicine · 2022Review
- The Role of Zinc in Antiviral Immunity.Advances in nutrition (Bethesda, Md.) · 2019Review
- Article
- Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application.Journal of pharmaceutics · 2016Article
- Zinc therapy in dermatology: a review.Dermatology research and practice · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerpes genitalis is one of the commonest sexually transmitted infections in the world caused by herpes simplex virus (HSV) 1 and 2. All herpes viruses show latency. Herpes genitalis caused by HSV-1 and HSV-2 is recurrent in 55 and 90% of case respectively.
aimsTo comparatively evaluate the therapeutic efficacy of topical zinc sulfate (ZnSO4) in varying concentrations in herpes genitalis. MATERIALS AND
methodsNinety patients clinically diagnosed as herpes genitalis and confirmed by Tzanck test were taken up for study and divided into 3 groups of 30 patients each which were applied topical ZnSO4 in concentrations of 1%, 2% and 4% respectively for 3 months. Ten patients of herpes genitalis were kept as control in whom only distilled water was applied. Patients were followed up for a total period of 6 months for any recurrences.
resultsTen patients of group 1 (1% ZnSO4) showed recurrence, 6 patients in group 2 (2% ZnSO4) and only one patient in group 3 (4% ZnSO4) showed recurrence. In the control group, 8 out of 10 patients showed recurrence. No serious side effects were seen in all 3 groups.
conclusionTopical ZnSO4 has been found to be an effective therapeutic modality not only for treatment but also for prolonging remissions in herpes genitalis. Topical 4% ZnSO4 has been found to be most efficacious out of the three concentrations, without any side effects.
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