ArticleMicrobiology (Reading, England)2013
Salmonella enterica serovar Typhimurium BaeSR two-component system positively regulates sodA in response to ciprofloxacin.
Article in Microbiology (Reading, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Oxidative stress-triggered UMPylation of SodA by YdiU modulates oxidative stress resistance in Salmonella.Veterinary research · 2026Article
- Functional Characterization of the Histidine Kinase BaeS Reveals Critical Residues for BaeSR-Dependent Stress Signaling inMicroorganisms · 2026Article
- RpoE mediates environmental stress tolerance and biofilm formation in foodborneCurrent research in food science · 2026Article
- The CitAB two-component system is involved in pathogenesis regulation in Avian pathogenic3 Biotech · 2025Article
- Roles of Response Regulators in the Two-Component System in the Formation of Stress Tolerance, Motility and Biofilm inFoods (Basel, Switzerland) · 2024Article
- Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.PloS one · 2023Article
- Impact ofEvolution letters · 2022Article
- Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection.eLife · 2021Article
- Polymyxins, the last-resort antibiotics: Mode of action, resistance emergence, and potential solutions.Journal of biosciences · 2021Review
- Genomic Variation and Arsenic Tolerance Emerged as Niche Specific Adaptations by DifferentFrontiers in microbiology · 2020Article
- The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies.Journal of pathogens · 2018Article
- Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain.International journal of molecular sciences · 2014Article
- Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas.Frontiers in microbiology · 2014Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to antibiotics, bacteria activate regulatory systems that control the expression of genes that participate in detoxifying these compounds, like multidrug efflux systems. We previously demonstrated that the BaeSR two-component system from Salmonella enterica serovar Typhimurium (S. Typhimurium) participates in the detection of ciprofloxacin, a bactericidal antibiotic, and in the positive regulation of mdtA, an efflux pump implicated in antibiotic resistance. In the present work, we provide further evidence for a role of the S. Typhimurium BaeSR two-component system in response to ciprofloxacin treatment and show that it regulates sodA expression. We demonstrate that, in the absence of BaeSR, the transcript levels of sodA and the activity of its gene product are lower. Using electrophoretic mobility shift assays and transcriptional fusions, we demonstrate that BaeR regulates sodA by a direct interaction with the promoter region.
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