ArticleGenome biology and evolution2013
Small, smaller, smallest: the origins and evolution of ancient dual symbioses in a Phloem-feeding insect.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers.
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185 citing papers in PubMed, 338 citations in OpenAlex.
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- Multi-Omics Profiling of the Scaphoideus titanus Yeast-Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects.Environmental microbiology · 2026Article
- Phylogenetically diverse MucoralesMicrobial genomics · 2026Article
- Stable nutritional endosymbiosis across cryptic diversity of a leafhopper species complex.BMC genomics · 2026Article
- Evolutionary signals in metabolic networks of insect endosymbionts revealed through comparative topological modeling.BMC genomics · 2026Article
- Complementary Microscopic and Metabarcoding Studies Allow for a Better Understanding of the Symbiotic Microbiome of Leafhopper Species Iassus lanio (Hemiptera, Cicadellidae).Microbial ecology · 2026Article
- Phylogenomics, population structure, and symbiont diversity refine the systematics of Southeast Asian rice leafhoppers (Hemiptera: Cicadellidae).Journal of insect science (Online) · 2026Article
- Symbiotic Diversity of Sap-Feeding Auchenorrhyncha (Hemiptera) in the Upland Landscapes of Central Cardamom Mountains, Cambodia.Microbial ecology · 2026Article
- Convergent extreme reductive evolution in ancient planthopper symbioses.Nature communications · 2026Article
- Contrasting Genomic Trajectories of Bartonellaceae Symbionts of Planthoppers.Genome biology and evolution · 2025Article
- Genome degradation results in nested symbiosis and endosymbiont replacement in cicadas.Nature communications · 2025Article
- Evolutionary dynamics of obligate endosymbiosis in the psyllid genus Cacopsylla.Communications biology · 2025Article
- Symbiont Diversity of Rice-Associated Leafhoppers (Cicadellidae) in the Tropical Floodplains of the Tonle Sap Lake, Cambodia.Microbial ecology · 2025Article
- Microbiomes of 2024's Periodical Cicada Brood XIII Vary By Species and Location.Microbial ecology · 2025Article
- The Endosymbiont Consortia of Two Cixiidae Planthoppers Reveal an Ancient Symbiosis With 'Candidatus Mirabilia Symbiotica'.Environmental microbiology reports · 2025Article
- Primary and Secondary Symbionts of Cambodian Cicadellidae and the Role of Parasitisation.Environmental microbiology reports · 2025Article
- Decoding the Minimal Translation System of the Plasmodium falciparum Apicoplast: Essential tRNA-modifying Enzymes and Their Roles in Organelle Maintenance.Journal of molecular biology · 2025Article
- Innovative data augmentation strategy for deep learning on biological datasets with limited gene representations focused on chloroplast genomes.Scientific reports · 2025Article
125 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many insects rely on bacterial symbionts with tiny genomes specialized for provisioning nutrients lacking in host diets. Xylem sap and phloem sap are both deficient as insect diets, but differ dramatically in nutrient content, potentially affecting symbiont genome evolution. For sap-feeding insects, sequenced symbiont genomes are available only for phloem-feeding examples from the suborder Sternorrhyncha and xylem-feeding examples from the suborder Auchenorrhyncha, confounding comparisons. We sequenced genomes of the obligate symbionts, Sulcia muelleri and Nasuia deltocephalinicola, of the phloem-feeding pest insect, Macrosteles quadrilineatus (Auchenorrhyncha: Cicadellidae). Our results reveal that Nasuia-ALF has the smallest bacterial genome yet sequenced (112 kb), and that the Sulcia-ALF genome (190 kb) is smaller than that of Sulcia in other insect lineages. Together, these symbionts retain the capability to synthesize the 10 essential amino acids, as observed for several symbiont pairs from xylem-feeding Auchenorrhyncha. Nasuia retains genes enabling synthesis of two amino acids, DNA replication, transcription, and translation. Both symbionts have lost genes underlying ATP synthesis through oxidative phosphorylation, possibly as a consequence of the enriched sugar content of phloem. Shared genomic features, including reassignment of the UGA codon from Stop to tryptophan, and phylogenetic results suggest that Nasuia-ALF is most closely related to Zinderia, the betaproteobacterial symbiont of spittlebugs. Thus, Nasuia/Zinderia and Sulcia likely represent ancient associates that have co-resided in hosts since the divergence of leafhoppers and spittlebugs >200 Ma, and possibly since the origin of the Auchenorrhyncha, >260 Ma.
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