ArticleThe Journal of physiology2013
Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Article
- Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.Neuroscience · 2021Review
- Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal.Frontiers in synaptic neuroscience · 2021Article
- Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens.Scientific reports · 2019Article
- Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder.Journal of clinical medicine · 2019Review
- The future of rodent models in depression research.Nature reviews. Neuroscience · 2019Review
- VTA GABA Neurons at the Interface of Stress and Reward.Frontiers in neural circuits · 2019Review
- PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Article
- Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.Cell death & disease · 2016Article
- Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stress and VTA synapses: implications for addiction and depression.The European journal of neuroscience · 2014Review
- Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.Neuron · 2014Article
- The multilingual nature of dopamine neurons.Progress in brain research · 2014Review
- VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems.Frontiers in behavioral neuroscience · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Synaptic projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) make up the backbone of the brain reward pathway, a neural circuit that mediates behavioural responses elicited by natural rewards as well as by cocaine and other drugs of abuse. In addition to the well-known modulatory dopaminergic projection, the VTA also provides fast excitatory and inhibitory synaptic input to the NAc, directly regulating NAc medium spiny neurons (MSNs). However, the cellular nature of VTA-to-NAc fast synaptic transmission and its roles in drug-induced adaptations are not well understood. Using viral-mediated in vivo expression of channelrhodopsin 2, the present study dissected fast excitatory and inhibitory synaptic transmission from the VTA to NAc MSNs in rats. Our results suggest that, following repeated exposure to cocaine (15 mg kg(-1) day(-1) × 5 days, i.p., 1 or 21 day withdrawal), a presynaptic enhancement of excitatory transmission and suppression of inhibitory transmission occurred at different withdrawal time points at VTA-to-NAc core synapses. In contrast, no postsynaptic alterations were detected at either type of synapse. These results suggest that changes in VTA-to-NAc fast excitatory and inhibitory synaptic transmissions may contribute to cocaine-induced alteration of the brain reward circuitry.
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Registered trials
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