ReviewThe Journal of physiology2014
Defining the neurocircuitry of exercise hyperpnoea.
Review in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Runners maintain locomotor-respiratory coupling following isocapnic voluntary hyperpnea to task failure.European journal of applied physiology · 2015Trial
- Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise.The Journal of physiology · 2025Article
- Ventilatory response and dyspnea on exertion in children with obesity and respiratory symptoms.Respiratory physiology & neurobiology · 2025Article
- Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st-century perspective.Experimental physiology · 2024Review
- Hypothalamic Orexinergic Neurons Projecting to the Mesencephalic Locomotor Region Are Activated by Voluntary Wheel Running Exercise in Rats.Yonago acta medica · 2024Article
- Fractional amplitude of low-frequency fluctuations associated with μ-opioid and dopamine receptor distributions in the central nervous system after high-intensity exercise bouts.Frontiers in neuroimaging · 2024Article
- Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures.Current neuropharmacology · 2024Review
- A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses.Nature communications · 2022Article
- Review
- Article
- Neuromuscular and Perceptual Responses to Sub-Maximal Eccentric Cycling.Frontiers in physiology · 2019Article
- Article
- Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats.Journal of neurophysiology · 2016Article
- Does degree of alteration in effort sense caused by eccentric exercise significantly affect initial exercise hyperpnea in humans?Journal of physiological anthropology · 2016Article
- Role played by periaqueductal gray neurons in parasympathetically mediated fear bradycardia in conscious rats.Physiological reports · 2016Article
- Article
- Type III-IV muscle afferents are not required for steady-state exercise hyperpnea in healthy subjects and patients with COPD or heart failure.Respiratory physiology & neurobiology · 2015Article
- Neural Control of Breathing and CO2 Homeostasis.Neuron · 2015Review
- FEV1 can be associated with reduced values after vigorous exercise in healthy adolescents.Annals of the American Thoracic Society · 2015Article
- Cardiovascular Reflexes Activity and Their Interaction during Exercise.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One hundred years ago in this journal, Krogh and Lindhard published a seminal paper highlighting the importance of the brain in the control of breathing during exercise. This symposium report reviews the historical developments that have taken place since 1913, and attempts to place the detailed neurocircuitry thought to underpin exercise hyperpnoea into context by focusing on key structures that might form the command network. With the advent of enhanced neuroimaging and functional neurosurgical techniques, a unique window of opportunity has recently arisen to target potential circuits in humans. Animal studies have identified a priori sites of interest in mid-brain structures, in particular the subthalamic locomotor region (subthalamic nucleus, STN) and the periaqueductal grey (PAG), which have now been recorded from in humans during exercise. When all data are viewed in an integrative manner, the PAG, in particular the lateral PAG, and aspects of the dorsal lateral PAG, appear to be key communicating circuitry for 'central command'. Moreover, the PAG also fulfils many requirements of a command centre. It has functional connectivity to higher centres (dorsal lateral prefrontal cortex) and the basal ganglia (in particular, the STN), and receives a sensory input from contracting muscle, but, importantly, it sends efferent information to brainstem nuclei involved in cardiorespiratory control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.