ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013
Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 60 citations in OpenAlex.
- Intra-individual Gene Expression Variability of Histologically Normal Breast Tissue.Scientific reports · 2018Trial
- Methylation profiling of normal tissue adjacent to breast tumors reveals two distinct groups with divergent tumor microenvironment features.NPJ breast cancer · 2026Article
- Compact breast parenchyma: imaging and transcriptomic correlates.Journal of translational medicine · 2026Article
- Myosin-actin pattern links matrix stiffness to GFAT2-hyaluronan metabolism.Materials today. Bio · 2025Article
- Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers.NPJ breast cancer · 2023Article
- Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women.Breast cancer research : BCR · 2022Article
- Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy.Breast cancer research : BCR · 2021Article
- Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer.Molecular cancer research : MCR · 2021Article
- The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure.Immunology and cell biology · 2020Article
- Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy.Journal of clinical medicine · 2020Review
- Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy.Journal of clinical medicine · 2020Article
- Collagen and PAPP-A in the Etiology of Postpartum Breast Cancer.Hormones & cancer · 2019Review
- Vascular density of histologically benign breast tissue from women with breast cancer: associations with tissue composition and tumor characteristics.Human pathology · 2019Article
- Associations between mammographic density and tumor characteristics in Chinese women with breast cancer.Breast cancer research and treatment · 2019Article
- A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue.Journal of mammary gland biology and neoplasia · 2019Article
- Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism.Nature communications · 2019Article
- Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues.Breast cancer research and treatment · 2019Article
- Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density.NPJ breast cancer · 2019Article
- Adjusting for BMI in analyses of volumetric mammographic density and breast cancer risk.Breast cancer research : BCR · 2018Article
- Stroma modifies relationships between risk factor exposure and age-related epithelial involution in benign breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
purposePrevious studies of breast tissue gene expression have shown that the extratumoral microenvironment has substantial variability across individuals, some of which can be attributed to epidemiologic factors. To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study. EXPERIMENTAL
designBreast cancer cases were classified on the basis of a previously reported, biologically defined extratumoral gene expression signature with two subtypes: an Active subtype, which is associated with high expression of genes related to fibrosis and wound response, and an Inactive subtype, which has high expression of cellular adhesion genes. Mammographic density of the contralateral breast was assessed using pretreatment mammograms and a quantitative, reliable computer-assisted thresholding method. Breast tissue composition was evaluated on the basis of digital image analysis of tissue sections.
resultsThe Inactive extratumoral subtype was associated with significantly higher percentage mammographic density (PD) and dense area (DA) in univariate analysis (PD: P = 0.001; DA: P = 0.049) and in multivariable analyses adjusted for age and body mass index (PD: P = 0.004; DA: P = 0.049). Inactive/higher mammographic density tissue was characterized by a significantly higher percentage of stroma and a significantly lower percentage of adipose tissue, with no significant change in epithelial content. Analysis of published gene expression signatures suggested that Inactive/higher mammographic density tissue expressed increased estrogen response and decreased TGF-β signaling.
conclusionsBy linking novel molecular phenotypes with mammographic density, our results indicate that mammographic density reflects broad transcriptional changes, including changes in both epithelia- and stroma-derived signaling.
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