Trial reportYonsei medical journal2013
Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis.
Trial report in Yonsei medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Efficacy of commonly prescribed analgesics in the management of osteoarthritis: a systematic review and meta-analysis.Rheumatology international · 2018Pooled it
- High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.CartilagePooled it
- Exploring the analgesic effects of pregabalin for post-chikungunya arthralgia: a comparative double-blind study.Brazilian journal of anesthesiology (Elsevier)Trial
- Frequency and factors associated with neuropathic pain in patients with knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Preventive effects of crocin and meloxicam on morphine withdrawal symptoms in mice: behavioral and biochemical insights.BMC pharmacology & toxicology · 2025Article
- Psychotropic Drug Use in Korean Patients With Osteoarthritis.Journal of Korean medical science · 2025Article
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Pharmacological use of gamma-aminobutyric acid derivatives in osteoarthritis pain management: a systematic review.BMC rheumatology · 2022Article
- Low prevalence of neuropathic-like pain symptoms in long-term controlled acromegaly.Pituitary · 2022Article
- Consensus Guidelines on Interventional Therapies for Knee Pain (STEP Guidelines) from the American Society of Pain and Neuroscience.Journal of pain research · 2022Review
- Proposed Canadian Consensus Guidelines on Osteoarthritis Treatment Based on OA-COAST Stages 1-4.Frontiers in veterinary science · 2022Review
- Article
- Antidepressant and anticonvulsant prescription rates in patients with osteoarthritis: a population-based cohort study.Rheumatology (Oxford, England) · 2021Article
- [Rheumatic diseases and neuropathic pain : Diagnosis and treatment].Zeitschrift fur Rheumatologie · 2021Review
- 2017 update of the Turkish League Against Rheumatism (TLAR) evidence-based recommendations for the management of knee osteoarthritis.Rheumatology international · 2018Review
- Calcium channel modulation as a target in chronic pain control.British journal of pharmacology · 2018Review
- Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis?Archives of rheumatology · 2017Article
- The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis.Journal of pain research · 2017Article
- Association of neuropathic pain with ultrasonographic measurements of femoral cartilage thickness and clinical parameters in patients with knee osteoarthritis.Journal of physical therapy science · 2016Article
- Non-surgical treatments for the management of early osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteoarthritic pain is largely considered to be inflammatory pain. Sensory nerve fibers innervating the knee have been shown to be significantly damaged in rat models of knee osteoarthritis (OA) in which the subchondral bone junction is destroyed, and this induces neuropathic pain (NP). Pregabalin was developed as a pain killer for NP; however, there are no reports on pregabalin use in OA patients. The purpose of this study was to investigate the efficacy of pregabalin for pain in OA patients. MATERIALS AND
methodsEighty-nine knee OA patients were evaluated in this randomized prospective study. Patients were divided into meloxicam, pregabalin, and meloxicam+pregabalin groups. Pain scores were evaluated before and 4 weeks after drug application using a visual analogue scale (VAS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pain scales among groups were compared using a Kruskal-Wallis test.
resultsBefore drug application, there was no significant difference in VAS and WOMAC scores among the three groups (p>0.05). Significant pain relief was seen in the meloxicam+pregabalin group in VAS at 1, 2, and 4 weeks, and WOMAC score at 4 weeks, compared with the other groups (p<0.05). No significant pain relief was seen in the meloxicam only group in VAS during 4 weeks and WOMAC score at 4 weeks compared with the pregabalin only group (p>0.05).
conclusionMeloxicam+pregabalin was effective for pain in OA patients. This finding suggests that OA pain is a combination of inflammatory and NP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.