ArticleProceedings of the National Academy of Sciences of the United States of America2013
Forebrain dopamine neurons project down to a brainstem region controlling locomotion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 108 citations in OpenAlex.
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- Socially induced plasticity of the posterior tuberculum and motor behavior in zebrafish (Danio rerio).The Journal of experimental biology · 2024Article
- Olfactory Projections to Locomotor Control Centers in the Sea Lamprey.International journal of molecular sciences · 2024Article
- Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.Cell reports · 2024Article
- The Basal Ganglia and Mesencephalic Locomotor Region Connectivity Matrix.Current neuropharmacology · 2024Review
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Revisiting the two rhythm generators for respiration in lampreys.Frontiers in neuroanatomy · 2023Article
- Brainstem neural mechanisms controlling locomotion with special reference to basal vertebrates.Frontiers in neural circuits · 2023Review
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- The neural bases of vertebrate motor behaviour through the lens of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The Mesencephalic Locomotor Region: Beyond Locomotor Control.Frontiers in neural circuits · 2022Review
- Olfactory-induced locomotion in lampreys.Cell and tissue research · 2022Review
- Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Dopaminergic Control of Movement-Evolutionary Considerations.International journal of molecular sciences · 2021Review
- Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region.Frontiers in neural circuits · 2021Article
- Descending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The contribution of dopamine (DA) to locomotor control is traditionally attributed to ascending dopaminergic projections from the substantia nigra pars compacta and the ventral tegmental area to the basal ganglia, which in turn project down to the mesencephalic locomotor region (MLR), a brainstem region controlling locomotion in vertebrates. However, a dopaminergic innervation of the pedunculopontine nucleus, considered part of the MLR, was recently identified in the monkey. The origin and role of this dopaminergic input are unknown. We addressed these questions in a basal vertebrate, the lamprey. Here we report a functional descending dopaminergic pathway from the posterior tuberculum (PT; homologous to the substantia nigra pars compacta and/or ventral tegmental area of mammals) to the MLR. By using triple labeling, we found that dopaminergic cells from the PT not only project an ascending pathway to the striatum, but send a descending projection to the MLR. In an isolated brain preparation, PT stimulation elicited excitatory synaptic inputs into patch-clamped MLR cells, accompanied by activity in reticulospinal cells. By using voltammetry coupled with electrophysiological recordings, we demonstrate that PT stimulation evoked DA release in the MLR, together with the activation of reticulospinal cells. In a semi-intact preparation, stimulation of the PT elicited reticulospinal activity together with locomotor movements. Microinjections of a D1 antagonist in the MLR decreased the locomotor output elicited by PT stimulation, whereas injection of DA had an opposite effect. It appears that this descending dopaminergic pathway has a modulatory role on MLR cells that are known to receive glutamatergic projections and promotes locomotor output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.