ArticleJournal of lipid research2013
Heritability of metabolic syndrome traits in a large population-based sample.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits.Nature human behaviour · 2023Pooled it
- Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis.Journal of human hypertension · 2019Pooled it
- Heritability of the Severity of the Metabolic Syndrome in Whites and Blacks in 3 Large Cohorts.Circulation. Cardiovascular genetics · 2017Pooled it
- Genomic study of maternal lipid traits in early pregnancy concurs with four known adult lipid loci.Journal of clinical lipidologyPooled it
- Evaluation of population-specific polygenic risk scores for blood lipids: insights from Taiwanese cohorts and multiancestry meta-analysis.Frontiers in bioinformatics · 2026Article
- Adipocyte-specific Krüppel-like factor 14 overexpression confers sex-biased protection from weight gain on a high-fat diet.Physiological reports · 2025Article
- Improving genetic variant identification for quantitative traits using ensemble learning-based approaches.BMC genomics · 2025Article
- Common and rare genetic variation intersects with ancestry to influence human skin and plasma carotenoid concentrations.medRxiv : the preprint server for health sciences · 2024Article
- Genome-wide association study for metabolic syndrome reveals APOA5 single nucleotide polymorphisms with multilayered effects in Koreans.Lipids in health and disease · 2024Article
- Monogenic features of urolithiasis: A comprehensive review.Asian journal of urology · 2024Review
- The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns.Scientific reports · 2024Article
- Heterogeneity in familial clustering of metabolic syndrome components in the multiethnic GENNID study.Obesity (Silver Spring, Md.) · 2024Article
- Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study.Cardiovascular diabetology · 2023Article
- The evolutionary impact and influence of oestrogens on adipose tissue structure and function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Lifestyle and Health-Related Quality of Life Relationships Concerning Metabolic Disease Phenotypes on the Nutrimdea Online Cohort.International journal of environmental research and public health · 2022Article
- Article
- Characterization of interactions of dietary cholesterol with the murine and human gut microbiome.Nature microbiology · 2022Article
- Sex Differences in Adiposity and Cardiovascular Diseases.International journal of molecular sciences · 2022Review
- Familial Resemblance in Low-Density Lipoprotein Cholesterol Response to Statins in the Danish Population.Journal of the American Heart Association · 2022Article
- Glucose-Related Traits and Risk of Migraine-A Potential Mechanism and Treatment Consideration.Genes · 2022Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Heritability estimates of metabolic syndrome traits vary widely across studies. Some studies have suggested that the contribution of genes may vary with age or sex. We estimated the heritability of 11 metabolic syndrome-related traits and height as a function of age and sex in a large population-based sample of twin families (N = 2,792-27,021, for different traits). A moderate-to-high heritability was found for all traits [from H(2) = 0.47 (insulin) to H(2) = 0.78 (BMI)]. The broad-sense heritability (H(2)) showed little variation between age groups in women; it differed somewhat more in men (e.g., for glucose, H(2) = 0.61 in young females, H(2) = 0.56 in older females, H(2) = 0.64 in young males, and H(2)= 0.27 in older males). While nonadditive genetic effects explained little variation in the younger subjects, nonadditive genetic effects became more important at a greater age. Our findings show that in an unselected sample (age range, ~18-98 years), the genetic contribution to individual differences in metabolic syndrome traits is moderate to large in both sexes and across age. Although the prevalence of the metabolic syndrome has greatly increased in the past decades due to lifestyle changes, our study indicates that most of the variation in metabolic syndrome traits between individuals is due to genetic differences.
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