ArticleClinics (Sao Paulo, Brazil)2013
Temporal relationship of serum markers and tissue damage during acute intestinal ischemia/reperfusion.
Article in Clinics (Sao Paulo, Brazil), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Histological Evaluation of Insulin-like Growth Factor-I in Experimental Intestinal Ischemia-Reperfusion Injury: A Rat Study.Diseases (Basel, Switzerland) · 2026Article
- Diagnostic performance of specific oxidative stress biomarkers, acute phase proteins, and certain trace elements in different severities of equine colic.Journal of equine science · 2025Article
- Development and validation of a nomogram for predicting the risk of intestinal barrier dysfunction in patients after major abdominal surgery: a prospective cohort study.Frontiers in medicine · 2025Article
- Biomarkers of Intestinal Injury in Colic.Animals : an open access journal from MDPI · 2023Review
- Acute Mesenteric Ischemia.Clinics in colon and rectal surgery · 2022Review
- Biomarkers of gut injury in neonates - where are we in predicting necrotising enterocolitis?Frontiers in pediatrics · 2022Review
- Intestinal congestion and reperfusion injury: damage caused to the intestinal tract and distal organs.Bioscience reports · 2021Review
- Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation.Iranian journal of basic medical sciences · 2021Article
- Wael's surgical treatment of intestinal gangrene due to congenital internal hernia: A case report and review of literature.Clinical case reports · 2020Article
- Serological biomarkers for acute mesenteric ischemia.Annals of translational medicine · 2019Review
- Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease.BMC veterinary research · 2018Review
- DifferentialFrontiers in immunology · 2018Article
- SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis.The Journal of surgical research · 2017Article
- Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates.Emerging infectious diseases · 2017Article
- Effect of Candida albicans on Intestinal Ischemia-reperfusion Injury in Rats.Chinese medical journal · 2016Article
- Protective effect of Xuebijing injection against acute lung injury induced by left ventricular ischemia/reperfusion in rabbits.Experimental and therapeutic medicine · 2016Article
- Differential Cultivation ofFrontiers in immunology · 2016Article
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- Bacterial translocation and in vivo assessment of intestinal barrier permeability in rainbow trout (Oncorhynchus mykiss) with and without soyabean meal-induced inflammation.Journal of nutritional science · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt is essential to identify a serological marker of injury in order to study the pathophysiology of intestinal ischemia reperfusion. In this work, we studied the evolution of several serological markers after intestinal ischemia reperfusion injury in rats. The markers of non-specific cell damage were aspartate aminotransferase, alanine aminotransaminase, and lactic dehydrogenase, the markers of inflammation were tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta, and the markers of intestinal mucosal damage were intestinal fatty acid binding protein and D-lactate. We used Chiús classification to grade the histopathological damage.
methodsWe studied 35 Wistar rats divided into groups according to reperfusion time. The superior mesenteric artery was clamped for 30 minutes, and blood and biopsies were collected at 1, 3, 6, 12, 24, and 48 hours after reperfusion. We plotted the mean ± standard deviation and compared the baseline and maximum values for each marker using Student's t-test.
resultsThe maximum values of interleukin-1 beta and lactic dehydrogenase were present before the maximal histopathological damage. The maximum tumor necrosis factor alpha and D-lactate expressions coincided with histopathological damage. Alanine aminotransaminase and aspartate aminotransferase had a maximum expression level that increased following the histopathological damage. The maximum expressions of interluken-6 and intestinal fatty acid binding protein were not significantly different from the Sham treated group.
conclusionFor the evaluation of injury secondary to acute intestinal ischemia reperfusion with a 30 minute ischemia period, we recommend performing histopathological grading, quantification of D-lactate, which is synthesized by intestinal bacteria and is considered an indicator of mucosal injury, and quantification of tumor necrosis factor alpha as indicators of acute inflammation three hours after reperfusion.
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