ArticleClinics (Sao Paulo, Brazil)2013
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes.
Article in Clinics (Sao Paulo, Brazil), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Role of Exercise in Visceral Adipose Tissue Inflammation and Macrophage Polarization in Hypertensive Mice.International journal of molecular sciences · 2025Article
- Increased prevalence of cardio-cerebrovascular risk factors during the COVID-19 pandemic lockdown: a large, single center, cross-sectional study.BMC medicine · 2025Article
- Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus.Chonnam medical journal · 2025Review
- Subcutaneous Adipose Tissue Browning, Serum Orexin-A, and Insulin Resistance Following Aerobic Exercise in High-Fat Diet Obesity Male Wistar Rats.International journal of preventive medicine · 2021Article
- Multiple Applications of Different Exercise Modalities with Rodents.Oxidative medicine and cellular longevity · 2021Review
- The Influence of Physical Activity on the Bioactive Lipids Metabolism in Obesity-Induced Muscle Insulin Resistance.Biomolecules · 2020Review
- Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes.Toxicology reports · 2020Article
- Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats.International journal of medical sciences · 2020Article
- Article
- A Study on Neonatal Intake of Oleanolic Acid and Metformin in Rats (Molecules (Basel, Switzerland) · 2018Article
- Article
- Aerobic Exercise Training Attenuates Tumor Growth and Reduces Insulin Secretion in Walker 256 Tumor-Bearing Rats.Frontiers in physiology · 2018Article
- Capsaicinoids improve consequences of physical activity.Toxicology reports · 2018Article
- Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet.Redox report : communications in free radical research · 2017Article
- Moderate exercise training does not prevent the reduction in myocardial L-type CaPhysiological reports · 2017Article
- Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome.BMC complementary and alternative medicine · 2017Article
- Amelioration of Abnormalities Associated with the Metabolic Syndrome byOxidative medicine and cellular longevity · 2017Article
- Exercise. Eat. Repeat. Focus on "Prior exercise training blunts short-term high-fat diet-induced weight gain".American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Cardioprotective effects of voluntary exercise in a rat model: role of matrix metalloproteinase-2.Oxidative medicine and cellular longevity · 2015Article
- Mechanisms linking excess adiposity and carcinogenesis promotion.Frontiers in endocrinology · 2014Review
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Authors and funding
7 authors.
Funding
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Abstract
objectivesWe evaluated the effects of aerobic exercise training without dietary changes on cardiovascular and metabolic variables and on the expression of glucose transporter Type 4 in rats with metabolic syndrome.
methodsTwenty male spontaneously hypertensive rats received monosodium glutamate during the neonatal period. The animals were allocated to the following groups: MS (sedentary metabolic syndrome), MS-T (trained on a treadmill for 1 hour/day, 5 days/week for 10 weeks), H (sedentary spontaneously hypertensive rats) and H-T (trained spontaneously hypertensive rats). The Lee index, blood pressure (tail-cuff system), insulin sensitivity (insulin tolerance test) and functional capacity were evaluated before and after 10 weeks of training. Glucose transporter Type 4 expression was analyzed using Western blotting. The data were compared using analysis of variance (ANOVA) (p<0.05).
resultsAt baseline, the MS rats exhibited lower insulin sensitivity and increased Lee index compared with the H rats. Training decreased the body weight and Lee index of the MS rats (MS-T vs. MS), but not of the H rats (H-T vs. H). There were no differences in food intake between the groups. At the end of the experiments, the systolic blood pressure was lower in the two trained groups than in their sedentary controls. Whole-body insulin sensitivity increased in the trained groups. Glucose transporter Type 4 content increased in the heart, white adipose tissue and gastrocnemius muscle of the trained groups relative to their respective untrained groups.
conclusionIn conclusion, the present study shows that an isolated aerobic exercise training intervention is an efficient means of improving several components of metabolic syndrome, that is, training reduces obesity and hypertension and increases insulin sensitivity.
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