Observational studyClinics (Sao Paulo, Brazil)2013
Evaluation of sensitivity, motor and pain thresholds across the menstrual cycle through medium-frequency transcutaneous electrical nerve stimulation.
Observational study in Clinics (Sao Paulo, Brazil), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04234555 (What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?
Who cites it
9 citing papers in PubMed.
- Reliability of Electrical Threshold Testing for Assessing Sensory, Motor and Pain Thresholds: An Exploratory Study in Active Subjects.Journal of functional morphology and kinesiology · 2026Article
- Do Hormonal Fluctuations in Healthy Women Influence the Somatosensory Temporal Discrimination Threshold?Brain and behavior · 2025Article
- The Influence of the Menstrual Cycle on Electrical Thresholds for Sensory and Pain Perception: Implications for Exercise and Rehabilitation in Women With and Without Primary Dysmenorrhea-A Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Pelvic floor muscle activation amplitude at rest, during voluntary contraction, and during Valsalva maneuver-a comparison between those with and without provoked vestibulodynia.The journal of sexual medicine · 2025Observational
- Inter- and Intra-Examiner Reliability Study of Two-Point Discrimination Test (TPD) and Two-Point Estimation Task (TPE) in the Sacral Area of Pain-Free Individuals.Diagnostics (Basel, Switzerland) · 2023Article
- Menstrual migraine is caused by estrogen withdrawal: revisiting the evidence.The journal of headache and pain · 2023Review
- Is It Necessary to Adapt Training According to the Menstrual Cycle? Influence of Contraception and Physical Fitness Variables.Life (Basel, Switzerland) · 2023Article
- Article
- Sex and the migraine brain.Neurobiology of disease · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to identify variations in nervous thresholds in different phases of the menstrual cycle in eumenorrheic women and users of oral contraceptives.
methodAn observational study was performed including 56 volunteers, consisting of 30 eumenorrheic women who were non-users of oral contraceptives and 26 users of oral contraceptives. An electrical stimulator was employed to assess their nervous thresholds, with pulses applied at a fixed frequency of 2,500 Hz, modulated at 50 Hz, with phase variances of 20 μs, 50 μs and 100 μs. Sensitivity, motor and pain thresholds were evaluated during five menstrual cycle phases: phase 1 - menstrual, phase 2 - follicular, phase 3 - ovulatory, phase 4 - luteal and phase 5 - premenstrual.
resultsThe results indicated low sensitivity thresholds of 100 μs for non-users of oral contraceptives and 50 μs for oral contraceptive users in phase 5. Low motor thresholds of 20 μs, 50 μs and 100 μs were observed for non-users of oral contraceptives in phase 5, while that of oral contraceptive users was 100 μs. Finally, a low pain threshold of 100 μs was observed in phase 5, but only in the oral contraceptive group.
conclusionNervous thresholds vary systematically across the phases of the menstrual cycle, with or without the use of oral contraceptives. These variations should be taken into account during research performed in women.
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