Evidence map›Paper›PMID 23917647›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2015

Advances in MR imaging for cervical spondylotic myelopathy.

Benjamin M Ellingson, Noriko Salamon, Langston T Holly

Abstract readSystematic Review
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Understanding degenerative cervical myelopathy in musculoskeletal practice.The Journal of manual & manipulative therapy · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Pre-operative spinal cord perfusion quantified by DSC MRI as a predictor of post-operative prognosis in patients with cervical spondylotic myelopathy.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Metabolic changes of thalamus assessed byFrontiers in neurology · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Benjamin M EllingsonDepartment of Radiology, David Geffen UCLA School of Medicine, Los Angeles, USA.
Noriko Salamon
Langston T Holly
University of California, Los Angeles · US

Funding

Spinal and Cerebral biomarkers for measuring disease progression and prognosis in chronic spinal cord injuryR01NS078494 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELLINGSON, BENJAMIN M., HOLLY, LANGSTON TYLER · 2012 to 2022
$3.6M
MR Spectroscopy to Explore Spinal Cord Viability in Chronic Spinal Cord InjuryR21NS065419 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOLLY, LANGSTON TYLER · 2009 to 2010
$421k
NINDS NIH HHS 1R01NS078494-01A1NINDS NIH HHS 1R21NS065419-01A1NINDS NIH HHS R01 NS078494NINDS NIH HHS R21 NS065419
6 · The paper itself

Abstract

purposeTo outline the pathogenesis of cervical spondylotic myelopathy (CSM), the correlative abnormalities observed on standard magnetic resonance imaging (MRI), the biological implications and current status of diffusion tensor imaging (DTI), and MR spectroscopy (MRS) as clinical tools, and future directions of MR technology in the management of CSM patients.

methodsA systematic review of the pathogenesis and current state-of-the-art in MR imaging technology for CSM was performed.

resultsCSM is caused by progressive, degenerative, vertebral column abnormalities that result in spinal cord damage related to both primary mechanical and secondary biological injuries. The T2 signal change on conventional MRI is most commonly associated with neurological deficits, but tends not to be a sensitive predictor of recovery of function. DTI and MRS show altered microstructure and biochemistry that reflect patient-specific pathogenesis.

conclusionAdvanced imaging techniques, including DTI and MRS, show higher sensitivity to microstructural and biochemical changes within the cord, and may aid in management of CSM patients.

Indexed as

Magnetic Resonance ImagingAdultCervical VertebraeDiffusion Tensor ImagingFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedSpinal Cord DiseasesSpondylosis

Identifiers

PMID23917647
PMCPMC4879123
OpenAlexW2080441877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.