ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Neural correlates of reward-based spatial learning in persons with cocaine dependence.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Applications of Immersive Virtual Reality for Illicit Substance Use: A Systematic Review.Journal of studies on alcohol and drugs · 2024Pooled it
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- The effect of virtual reality modality level of immersion and locomotion on Spatial learning and gaze measures.Virtual reality · 2026Article
- Causal computations of supplementary motor area on spatial impulsivity.Scientific reports · 2024Article
- Relationship between carotid intima-media thickness (cIMT) and dual-system imbalance in tobacco dependence: An rs-fMRI research.Brain and behavior · 2023Article
- Resting-State Functional Magnetic Resonance Imaging Reveals Overactivation of the Habitual Control Brain System in Tobacco Dependence.Neuropsychiatric disease and treatment · 2021Article
- Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation.Pharmacology, biochemistry, and behavior · 2020Review
- Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status.Cerebral cortex communications · 2020Article
- Disrupted resting-state brain functional network in methamphetamine abusers: A brain source space study by EEG.PloS one · 2019Article
- Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.Developmental cognitive neuroscience · 2018Review
- Neural Mechanisms Underlying Time Perception and Reward Anticipation.Frontiers in human neuroscience · 2018Article
- Reward Prediction Errors in Drug Addiction and Parkinson's Disease: from Neurophysiology to Neuroimaging.Current neurology and neuroscience reports · 2017Review
- The roles of valuation and reward processing in cognitive function and psychiatric disorders.Annals of the New York Academy of Sciences · 2017Review
- Reward-Based Spatial Learning in Teens With Bulimia Nervosa.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Article
- Impaired Bayesian learning for cognitive control in cocaine dependence.Drug and alcohol dependence · 2015Article
- Psychostimulants and movement disorders.Frontiers in neurology · 2015Review
- Neurologic complications of illicit drug abuse.Continuum (Minneapolis, Minn.) · 2014Review
- Participation in a novel treatment component during residential substance use treatment is associated with improved outcome: a pilot study.Addiction science & clinical practice · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Dysfunctional learning systems are thought to be central to the pathogenesis of and impair recovery from addictions. The functioning of the brain circuits for episodic memory or learning that support goal-directed behavior has not been studied previously in persons with cocaine dependence (CD). Thirteen abstinent CD and 13 healthy participants underwent MRI scanning while performing a task that requires the use of spatial cues to navigate a virtual-reality environment and find monetary rewards, allowing the functional assessment of the brain systems for spatial learning, a form of episodic memory. Whereas both groups performed similarly on the reward-based spatial learning task, we identified disturbances in brain regions involved in learning and reward in CD participants. In particular, CD was associated with impaired functioning of medial temporal lobe (MTL), a brain region that is crucial for spatial learning (and episodic memory) with concomitant recruitment of striatum (which normally participates in stimulus-response, or habit, learning), and prefrontal cortex. CD was also associated with enhanced sensitivity of the ventral striatum to unexpected rewards but not to expected rewards earned during spatial learning. We provide evidence that spatial learning in CD is characterized by disturbances in functioning of an MTL-based system for episodic memory and a striatum-based system for stimulus-response learning and reward. We have found additional abnormalities in distributed cortical regions. Consistent with findings from animal studies, we provide the first evidence in humans describing the disruptive effects of cocaine on the coordinated functioning of multiple neural systems for learning and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.