ArticleJAMA2013
Reporting genomic sequencing results to ordering clinicians: incidental, but not exceptional.
Abstract read
In one paragraph
Article in JAMA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Newborn Sequencing in Genomic Medicine and Public Health.Pediatrics · 2017Trial
- Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.Annals of internal medicine · 2016Trial
- When bins blur: Patient perspectives on categories of results from clinical whole genome sequencing.AJOB empirical bioethicsTrial
- Navigating Genetic Testing in Nephrology: Options and Decision-Making Strategies.Kidney international reports · 2025Review
- Analogies in Genomics Policymaking: Debates and Drawbacks.American journal of human genetics · 2020Article
- Genomic Contextualism: Shifting the Rhetoric of Genetic Exceptionalism.The American journal of bioethics : AJOB · 2019Article
- Reconciling Opportunistic and Population Screening in Clinical Genomics.Mayo Clinic proceedings · 2019Review
- Impact of Receiving Secondary Results from Genomic Research: A 12-Month Longitudinal Study.Journal of genetic counseling · 2018Article
- Interest and Attitudes of Patients With Advanced Cancer With Regard to Secondary Germline Findings From Tumor Genomic Profiling.Journal of oncology practice · 2017Article
- Informed consent for next-generation nucleotide sequencing studies: Aiding communication between participants and investigators.Journal of clinical and translational science · 2017Article
- Article
- Decision-Making Preferences About Secondary Germline Findings That Arise From Tumor Genomic Profiling Among Patients With Advanced Cancers.JCO precision oncology · 2017Article
- Aggregate penetrance of genomic variants for actionable disorders in European and African Americans.Science translational medicine · 2016Article
- Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing.European journal of human genetics : EJHG · 2016Article
- Genomic sequencing in clinical practice: applications, challenges, and opportunities.Dialogues in clinical neuroscience · 2016Review
- Genomic Testing: a Genetic Counselor's Personal Reflection on Three Years of Consenting and Testing.Journal of genetic counseling · 2016Article
- Molecular diagnostic experience of whole-exome sequencing in adult patients.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.American journal of human genetics · 2016Article
- Clinical genomics: from a truly personal genome viewpoint.Human genetics · 2016Review
- Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.Journal of personalized medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Robert C GreenDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. rcgreen@genetics.med.harvard.edu
James R Lupski
Leslie G Biesecker
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MGenomic Ascertainment - Molecular and Genetic AspectsZIAHG200359 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, LESLIE · 2009 to 2025
$19.7MBaylor-Johns Hopkins Center for Mendelian GeneticsU54HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2012 to 2015
$15.6MGenomic Ascertainment - Clinical and Behavioral AspectsZIAHG200387 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, LESLIE · 2013 to 2025
$15.5MBaylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5MRisk Evaluation and Education for Alzheimer's Disease (REVEAL IV)R01HG002213 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C. · 1999 to 2012
$7.6MNonrecurrent rearrangements, genome architecture and neurodegenerative disease.R01NS058529 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI LUPSKI, JAMES R. · 2009 to 2017
$5.0MDisclosing Genomic Incidental Findings in a Cancer Biobank: An ELSI ExperimentR01CA154517 · NCI · MAYO CLINIC ROCHESTER · PI KOENIG, BARBARA A., PETERSEN, GLORIA M. · 2011 to 2015
$2.7MManaging Incidental Findings in Human Subjects ResearchR01HG003178 · NHGRI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WOLF, SUSAN M. · 2005 to 2010
$1.5MImpact of Direct to Consumer Genetic TestingR01HG005092 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C., ROBERTS, SCOTT · 2010 to 2012
$1.1MReturning research results in children: Parental Preferences and Expert OversightR01HG006615 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI HOLM, INGRID ADELE · 2011 to 2013
$361kIntramural NIH HHSNCI NIH HHS CA154517NCI NIH HHS R01 CA154517NHGRI NIH HHS HG003178NHGRI NIH HHS HG005092NHGRI NIH HHS HG006542NHGRI NIH HHS HG006615NHGRI NIH HHS HG02213NHGRI NIH HHS R01 HG002213NHGRI NIH HHS R01 HG003178NHGRI NIH HHS R01 HG005092NHGRI NIH HHS R01 HG006615NHGRI NIH HHS U54 HG003273NHGRI NIH HHS U54 HG006542NHGRI NIH HHS UM1 HG006542NINDS NIH HHS NS058529NINDS NIH HHS R01 NS058529
Abstract
PubMed holds no abstract for this paper.
Indexed as
Incidental FindingsMandatory ReportingSequence Analysis, DNADisclosureGenetic Predisposition to DiseaseGenetic TestingHumansMutationPersonal AutonomyRisk
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.