ArticleMathematical biosciences2013
Impact of flow on ligand-mediated bacterial flocculation.
Article in Mathematical biosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- Surface deformation and shear flow in ligand mediated cell adhesion.Journal of mathematical biology · 2016Article
- Ligand-mediated adhesive mechanics of two static, deformed spheres.The European physical journal. E, Soft matter · 2016Article
- Sticky surface: sphere-sphere adhesion dynamics.Journal of biological dynamics · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To understand the adhesion-fragmentation dynamics of bacterial aggregates (i.e., flocs), we model the aggregates as two ligand-covered rigid spheres. We develop and investigate a model for the attachment/detachment dynamics in a fluid subject to a homogeneous planar shear-flow. The binding ligands on the surface of the flocs experience attractive and repulsive surface forces in an ionic medium and exhibit finite resistance to rotation (via bond tilting). For certain range of material and fluid parameters, our results predict a nonlinear or hysteretic relationship between the binding/unbinding of the floc surface and the net floc velocity (translational plus rotational velocity). We show that the surface adhesion is promoted by increased fluid flow until a critical value, beyond which the bonds starts to yield. Moreover, adhesion is not promoted in a medium with low ionic strength, or flocs with bigger size or higher binder stiffness. The numerical simulations of floc-aggregate number density studies support these findings.
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Registered trials
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